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MCPH1 Antikörper (AA 11-110) (FITC)

This anti-MCPH1 antibody (ABIN1390028) is a Rabbit Polyclonal antibody detecting MCPH1 in WB, IF (cc), IF (p). Suitable for Mouse.
Produktnummer ABIN1390028

Kurzübersicht für MCPH1 Antikörper (AA 11-110) (FITC) (ABIN1390028)

Target

Alle MCPH1 Antikörper anzeigen
MCPH1 (Microcephalin 1 (MCPH1))

Reaktivität

  • 39
  • 22
  • 4
  • 1
Maus

Wirt

  • 46
  • 6
  • 1
Kaninchen

Klonalität

  • 48
  • 5
Polyklonal

Konjugat

  • 28
  • 3
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser MCPH1 Antikörper ist konjugiert mit FITC

Applikation

  • 44
  • 22
  • 12
  • 12
  • 12
  • 4
  • 3
  • 3
  • 2
  • 1
Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
  • Bindungsspezifität

    • 14
    • 9
    • 6
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 11-110

    Kreuzreaktivität

    Maus

    Homologie

    Human,Dog

    Aufreinigung

    Purified by Protein A.

    Immunogen

    KLH conjugated synthetic peptide derived from human Microcephalin 1/BRIT1

    Isotyp

    IgG
  • Applikationshinweise

    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Konzentration

    1 μg/μL

    Buffer

    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

    Konservierungsmittel

    ProClin

    Vorsichtsmaßnahmen

    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

    Lagerung

    -20 °C

    Informationen zur Lagerung

    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

    Haltbarkeit

    12 months
  • Target

    MCPH1 (Microcephalin 1 (MCPH1))

    Andere Bezeichnung

    Microcephalin 1/BRIT1

    Hintergrund

    Synonyms: BRCT repeat inhibitor of TERT expression 1, BRIT 1, FLJ12847, Hypothetical protein FLJ12847, MCPH 1, MCPH1, MCPH1_HUMAN, MCT antibody Microcephalin 1, Microcephalin-1, Microcephaly primary autosomal recessive 1.

    Background: Microcephalin modulates brain size and has been proliferating under strong positive selection for several thousand years, although the nature of the positive selection is poorly understood. Human Microcephalin contains three BRCA1 C-terminal (BRCT) domains and shares 57 % identity with its mouse ortholog, the most conserved regions being BRCT domains where there is 80 % identity. Predominant expression of human Microcephalin is observed in fetal brain, liver and kidney tissues and is expressed during neurogenesis in mice. Microcephalin displays significantly higher rates of protein evolution in primates than in rodents, this trend is most noticeable for the subset of genes associated with nervous system development. Microcephalin has a very young, single nucleotide, polymorphism haplotype associated with modern humans, this gene is presumably still evolving in Homo sapiens. It functions in DNA damage response and regulation of cell cycle checkpoints.

    Pathways

    Stem Cell Maintenance
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