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MCPH1 Antikörper (Microcephalin 1) AA 11-110 Primary Antibody

MCPH1 Reaktivität: Maus ELISA, ICC, IF (cc), IF (p), IHC (fro), IHC (p), WB Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN1385183
$374.00
Zzgl. Versandkosten $45.00
100 μL
local_shipping Lieferung nach: Vereinigte Staaten von Amerika
Lieferung in 4 bis 6 Werktagen
  • Target Alle MCPH1 Antikörper anzeigen
    MCPH1
    Bindungsspezifität
    • 14
    • 12
    • 10
    • 6
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 11-110
    Reaktivität
    • 46
    • 23
    • 4
    • 1
    Maus
    Wirt
    • 52
    • 7
    • 1
    Kaninchen
    Klonalität
    • 54
    • 6
    Polyklonal
    Konjugat
    • 27
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser MCPH1 Antikörper ist unkonjugiert
    Applikation
    • 42
    • 27
    • 12
    • 12
    • 12
    • 4
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    ELISA, Immunocytochemistry (ICC), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
    Homologie
    Human,Dog
    Aufreinigung
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human Microcephalin 1/BRIT1
    Isotyp
    IgG
  • Applikationshinweise
    WB 1:300-5000
    ELISA 1:500-1000
    IHC-P 1:200-400
    IHC-F 1:100-500
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    ICC 1:100-500
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 μg/μL
    Buffer
    0.01M TBS( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Vorsichtsmaßnahmen
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
    Haltbarkeit
    12 months
  • Target
    MCPH1
    Andere Bezeichnung
    Microcephalin 1/BRIT1 (MCPH1 Produkte)
    Synonyme
    RGD1560642, MGC83773, MCPH1, mct, brit1, MGC148665, BRIT1, MCT, 5430437K10Rik, D030046N04Rik, microcephalin 1, microcephalin 1 S homeolog, microcephaly, primary autosomal recessive 1, Mcph1, mcph1.S, MCPH1, mcph1
    Hintergrund

    Microcephalin modulates brain size and has been proliferating under strong positive selection for several thousand years, although the nature of the positive selection is poorly understood. Human Microcephalin contains three BRCA1 C-terminal (BRCT) domains and shares 57 % identity with its mouse ortholog, the most conserved regions being BRCT domains where there is 80 % identity. Predominant expression of human Microcephalin is observed in fetal brain, liver and kidney tissues and is expressed during neurogenesis in mice. Microcephalin displays significantly higher rates of protein evolution in primates than in rodents, this trend is most noticeable for the subset of genes associated with nervous system development. Microcephalin has a very young, single nucleotide, polymorphism haplotype associated with modern humans, this gene is presumably still evolving in Homo sapiens. It functions in DNA damage response and regulation of cell cycle checkpoints.

    Subcellular location: Cytoplasm

    Synonyms: BRCT repeat inhibitor of TERT expression 1, BRIT 1, FLJ12847, Hypothetical protein FLJ12847, MCPH 1, MCPH1, MCPH1_HUMAN, MCT antibody Microcephalin 1, Microcephalin-1, Microcephaly primary autosomal recessive 1.

    Pathways
    Stem Cell Maintenance
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