Cullin 5 Antikörper (AA 701-780) (AbBy Fluor® 488)

Produktnummer ABIN1388422

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch Cullin 5 in IF (cc) und IF (p). Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für Cullin 5 Antikörper (AA 701-780) (AbBy Fluor® 488) (ABIN1388422)

Target: Cullin 5 (CUL5)

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Cullin 5 Antikörper ist konjugiert mit AbBy Fluor® 488

Applikation: Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Produktdetails anti-Cullin 5 Antikörper (AbBy Fluor® 488)

Bindungsspezifität: AA 701-780

Homologie: Human,Mouse,Rat,Dog,Cow,Horse,Rabbit

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human Cullin 5

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Haltbarkeit: 12 months

Details zu Cullin 5

Target: Cullin 5 (CUL5)

Andere Bezeichnung: Cullin 5

Hintergrund:

Synonyms: CUL 5, CUL-5, CUL5, CUL5_HUMAN, Cullin-5, Cullin5, VACM 1, VACM-1, VACM1, Vasopressin activated calcium mobilizing receptor 1, Vasopressin activated calcium mobilizing receptor, Vasopressin-activated calcium-mobilizing receptor 1.

Background: Core component of multiple SCF-like ECS (Elongin-Cullin 2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. ECS(SOCS1) seems to direct ubiquitination of JAk2. Seems to be involved poteosomal degradation of p53/TP53 stimulated by adenovirus E1B-55 kDa protein. May form a cell surface vasopressin receptor.

Gen-ID: 1729

Pathways: Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development