MPL Antikörper (AA 401-500)

Produktnummer ABIN1387832

Produktdetails anti-MPL Antikörper

Target: MPL (Myeloproliferative Leukemia Virus Oncogene (MPL))

Bindungsspezifität: AA 401-500

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MPL Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Kreuzreaktivität: Human, Maus

Homologie: Rat,Rabbit

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human TPOR

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:300-5000
ELISA 1:500-1000
FCM 1:20-100
IHC-P 1:200-400

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Haltbarkeit: 12 months

Details zu MPL

Target: MPL (Myeloproliferative Leukemia Virus Oncogene (MPL))

Andere Bezeichnung: TPOR (MPL Produkte)

Synonyme: C-MPL antikoerper, CD110 antikoerper, MPLV antikoerper, THCYT2 antikoerper, TPOR antikoerper, TPO-R antikoerper, c-mpl antikoerper, c-mpl-I antikoerper, c-mpl-II antikoerper, hlb219 antikoerper, MPL antikoerper, mpll antikoerper, tpor antikoerper, tpor.b antikoerper, MPL proto-oncogene, thrombopoietin receptor antikoerper, myeloproliferative leukemia virus oncogene antikoerper, MPL antikoerper, Mpl antikoerper, mpl antikoerper

Hintergrund:

Synonyms: C MPL, C-MPL, CMPL, CD110, CD 110, MPL, MPLV, Myeloprolerative leukemia protein, Myeloprolerative leukemia virus oncogene, Proto-oncogene c-Mpl, THCYT2, Thrombopoietin receptor, TPO R, TPO-R, TPOR, TPOR_HUMAN.

Background: Thrombopoietin (TPO or THPO), also known as c-Mpl ligand (c-Mpl L), is a cytokine that plays a central role in megakaryopoiesis by influencing the development and maturation of megakaryocytes and platelet production from hematopoietic stem cells. TPO exerts its biological effects through the TPO receptor, c-Mpl. c-Mpl is a member of the cytokine receptor superfamily. Expression of c-Mpl is restricted to hematopoietic tissues and cells, such as bone marrow, spleen, fetal liver and CD34+ cells. Stimulation of c-Mpl with TPO results in the activation of the Janus tyrosine kinase family members, Tyk 2 and JAK2, which in turn phosphorylate Stat5 and Stat3, causing their nuclear translocation and the transcription of Stat responsive genes. Muta-tions in c-Mpl have been implicated as the cause of certain human disorders, including congenital amegakaryocytic thrombocytopenia (CAMT) and thrombocytopenia with absent radii (TAR) syndrome.

Pathways: JAK-STAT Signalweg