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GFI1B Antikörper

GFI1B Reaktivität: Human, Maus, Ratte WB, IF (p), IHC (p) Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN1387214
  • Target Alle GFI1B Antikörper anzeigen
    GFI1B (Growth Factor Independent 1B Transcription Repressor (GFI1B))
    Reaktivität
    • 26
    • 20
    • 17
    • 2
    • 2
    • 2
    • 1
    • 1
    Human, Maus, Ratte
    Wirt
    • 24
    • 2
    Kaninchen
    Klonalität
    • 26
    Polyklonal
    Konjugat
    • 12
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser GFI1B Antikörper ist unkonjugiert
    Applikation
    • 25
    • 12
    • 5
    • 4
    • 4
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Kreuzreaktivität
    Human, Maus, Ratte
    Aufreinigung
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human GFI1B
    Isotyp
    IgG
    Top Product
    Discover our top product GFI1B Primärantikörper
  • Applikationshinweise
    WB 1:300-5000
    IHC-P 1:200-400
    IF(IHC-P) 1:50-200
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 μg/μL
    Buffer
    0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
    Konservierungsmittel
    ProClin
    Vorsichtsmaßnahmen
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Lagerung
    4 °C,-20 °C
    Informationen zur Lagerung
    Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
    Haltbarkeit
    12 months
  • Target
    GFI1B (Growth Factor Independent 1B Transcription Repressor (GFI1B))
    Andere Bezeichnung
    GFI1B (GFI1B Produkte)
    Synonyme
    GFI1B antikoerper, GFI antikoerper, znf544 antikoerper, MGC80648 antikoerper, Gfi-1B antikoerper, growth factor independent 1B transcriptional repressor antikoerper, growth factor independent 1B transcription repressor L homeolog antikoerper, Zinc finger protein Gfi-1b antikoerper, growth factor independent 1B antikoerper, GFI1B antikoerper, Gfi1b antikoerper, gfi1b.L antikoerper, gfi1b antikoerper
    Hintergrund

    Synonyms: Potential regulator of CDKN1A translocated in CML, GFI 1B, GFI-1B, gfi1b, GFI1B protein, GFI1B_HUMAN, Growth factor independent 1B protein, Growth factor independent protein 1B, Potential regulator of CDKN1A, Translocated in CML, Zinc finger protein Gfi-1b.

    Background: Essential proto-oncogenic transcriptional regulator necessary for development and differentiation of erythroid and megakaryocytic lineages. Transcriptional repressor or activator depending on both promoter and cell type context, represses promoter activity of SOCS1 and SOCS3 and thus, may regulate cytokine signaling pathways. Cooperates with GATA1 to repress target gene transcription, such as the apoptosis regulator BCL2L1, GFI1B silencing in leukemic cell lines markedly increase apoptosis rate. Inhibits down-regulation of MYC and MYB as well as the cyclin-dependent kinase inhibitor CDKN1A/P21WAF1 in IL6-treated myelomonocytic cells. Represses expression of GATA3 in T-cell lymphomas and inhibits GATA1-mediated transcription, as GATA1 also mediates erythroid GFI1B transcription, both GATA1 and GFI1B participate in a feedback regulatory pathway controlling the expression of GFI1B gene in erythroid cells. Suppresses GATA1-mediated stimulation of GFI1B promoter through protein interaction. Binds to gamma-satellite DNA and to its own promoter, auto-repressing its own expression. Alters histone methylation by recruiting histone methyltransferase to target genes promoters. Plays a role in heterochromatin formation.

    Gen-ID
    8328
    Pathways
    Cellular Response to Molecule of Bacterial Origin
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