GFI1B Antikörper (C-Term)

Produktnummer ABIN1881370

Produktdetails anti-GFI1B Antikörper

Target: GFI1B (Growth Factor Independent 1B Transcription Repressor (GFI1B))

Bindungsspezifität: AA 302-330, C-Term

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser GFI1B Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Aufreinigung: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This GFI1B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 302-330 amino acids from the C-terminal region of human GFI1B.

Klon: RB44051

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Haltbarkeit: 6 months

Referenzen für anti-GFI1B Antikörper (ABIN1881370)

Huang, Kuo, Lai, Suzuki, Sugano, Chang: "GATA-1 and NF-Y cooperate to mediate erythroid-specific transcription of Gfi-1B gene." in: Nucleic acids research, Vol. 32, Issue 13, pp. 3935-46, (2004) (PubMed).

Rödel, Wagner, Zörnig, Niessing, Möröy: "The human homologue (GFI1B) of the chicken GFI gene maps to chromosome 9q34.13-A locus frequently altered in hematopoietic diseases." in: Genomics, Vol. 54, Issue 3, pp. 580-2, (1999) (PubMed).

Details zu GFI1B

Target: GFI1B (Growth Factor Independent 1B Transcription Repressor (GFI1B))

Andere Bezeichnung: GFI1B (GFI1B Produkte)

Synonyme: GFI1B antikoerper, GFI antikoerper, znf544 antikoerper, MGC80648 antikoerper, Gfi-1B antikoerper, growth factor independent 1B transcriptional repressor antikoerper, growth factor independent 1B transcription repressor L homeolog antikoerper, Zinc finger protein Gfi-1b antikoerper, growth factor independent 1B antikoerper, GFI1B antikoerper, Gfi1b antikoerper, gfi1b.L antikoerper, gfi1b antikoerper

Hintergrund: Essential proto-oncogenic transcriptional regulator necessary for development and differentiation of erythroid and megakaryocytic lineages. Component of a RCOR-GFI-KDM1A-HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development and controls hematopoietic differentiation. Transcriptional repressor or activator depending on both promoter and cell type context, represses promoter activity of SOCS1 and SOCS3 and thus, may regulate cytokine signaling pathways. Cooperates with GATA1 to repress target gene transcription, such as the apoptosis regulator BCL2L1, GFI1B silencing in leukemic cell lines markedly increase apoptosis rate. Inhibits down-regulation of MYC and MYB as well as the cyclin-dependent kinase inhibitor CDKN1A/P21WAF1 in IL6-treated myelomonocytic cells. Represses expression of GATA3 in T-cell lymphomas and inhibits GATA1-mediated transcription, as GATA1 also mediates erythroid GFI1B transcription, both GATA1 and GFI1B participate in a feedback regulatory pathway controlling the expression of GFI1B gene in erythroid cells. Suppresses GATA1-mediated stimulation of GFI1B promoter through protein interaction. Binds to gamma-satellite DNA and to its own promoter, auto-repressing its own expression. Alters histone methylation by recruiting histone methyltransferase to target genes promoters. Plays a role in heterochromatin formation.

Molekulargewicht: 37492

NCBI Accession: NP_001128503, NP_004179

UniProt: Q5VTD9

Pathways: Cellular Response to Molecule of Bacterial Origin