NCF1 Antikörper (pSer359)
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- Target Alle NCF1 Antikörper anzeigen
- NCF1 (Neutrophil Cytosol Factor 1 (NCF1))
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Bindungsspezifität
- pSer359
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Reaktivität
- Ratte
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser NCF1 Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB), ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunocytochemistry (ICC), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
- Kreuzreaktivität
- Ratte
- Homologie
- Human
- Aufreinigung
- Purified by Protein A.
- Immunogen
- KLH conjugated synthetic phosphopeptide derived from human NCF1 around the phosphorylation site of Ser359
- Isotyp
- IgG
- Top Product
- Discover our top product NCF1 Primärantikörper
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- Applikationshinweise
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WB 1:300-5000
ELISA 1:500-1000
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500 - Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- 1 μg/μL
- Buffer
- 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
- Konservierungsmittel
- ProClin
- Vorsichtsmaßnahmen
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- Lagerung
- 4 °C,-20 °C
- Informationen zur Lagerung
- Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
- Haltbarkeit
- 12 months
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Limb Remote Ischemic Postconditioning Reduces Ischemia-Reperfusion Injury by Inhibiting NADPH Oxidase Activation and MyD88-TRAF6-P38MAP-Kinase Pathway of Neutrophils." in: International journal of molecular sciences, Vol. 17, Issue 12, (2016) (PubMed).
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Limb Remote Ischemic Postconditioning Reduces Ischemia-Reperfusion Injury by Inhibiting NADPH Oxidase Activation and MyD88-TRAF6-P38MAP-Kinase Pathway of Neutrophils." in: International journal of molecular sciences, Vol. 17, Issue 12, (2016) (PubMed).
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- Target
- NCF1 (Neutrophil Cytosol Factor 1 (NCF1))
- Andere Bezeichnung
- NCF1/p47 phox (NCF1 Produkte)
- Synonyme
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NCF1A antikoerper, NOXO2 antikoerper, SH3PXD1A antikoerper, p47phox antikoerper, Ncf-1 antikoerper, p47
antikoerper, neutrophil cytosolic factor 1 antikoerper, NCF1 antikoerper, Ncf1 antikoerper - Hintergrund
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Synonyms: NCF1Ser359, p47 phoxSer359, NCF1 phospho S359, 47 kDa autosomal chronic granulomatous disease protein, 47 kDa neutrophil oxidase factor, NADPH oxidase organizer 2, NCF 47K, Neutrophil cytosol factor 1, Neutrophil cytosolic factor 1, Neutrophil NADPH oxidase factor 1, Nox organizer 2, Nox organizing protein 2, NOXO2, p47 phox, p47phox, ,SH3 and PX domain containing protein 1A, SH3PXD1A, NADPH oxidase p47 phox, NCF1_HUMAN.
Background: The heredity chronic granulomatous disease (CGF) has been linked to mutations in p47-phox and p67-phox. The cytosolic proteins p47-phox and p67-phox, also designated neutrophil cytosol factor (NCF)1 and NCF2, respectively, are required for activation of the superoxide-producing NADPH oxidase in neutrophils and other phagocytic cells. During activation of the NADPH oxidase, p47-phox and p67-phox migrate to the plasma membrane where they associate with cytochrome b558 and the small G protein Rac to form the functional enzyme complex. Both p47-phox and p67-phox contain two Src homology 3 (SH3) domains. The C-terminal SH3 domain of p67-phox has been shown to interact with the proline-rich domain of p47-phox, suggesting that p47-phox may faciliate the transport of p67-phox to the membrane.
- Gen-ID
- 653361
- Pathways
- PI3K-Akt Signalweg
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