UBXN6 Antikörper

Produktnummer ABIN1381743

Dieses Anti-UBXN6-Antikörper ist ein Maus Monoklonal-Antikörper zur Detektion von UBXN6 in WB, IF und IP. Geeignet für Human.

Kurzübersicht für UBXN6 Antikörper (ABIN1381743)

Target: UBXN6 (UBX Domain Protein 6 (UBXN6))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser UBXN6 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF), Immunoprecipitation (IP)

Klon: 5C3-1

Produktdetails anti-UBXN6 Antikörper

Spezifität: Detects both isoforms

Keine Kreuzreaktivität: Maus

Aufreinigung: purified

Immunogen: recombinant protein purified from bacteria

Isotyp: IgG1

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: 0.5 % PBS, 50 % glycerol, 0.1 % BSA

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C

Informationen zur Lagerung: short term: 2 °C - 8 °C, long term: -20 °C

Details zu UBXN6

Target: UBXN6 (UBX Domain Protein 6 (UBXN6))

Andere Bezeichnung: UBXD1 (Full Length and Short Isoform)

Hintergrund: P97 is a highly abundant and conserved member of the AAA family of ATPase. It has been termed an ubiquitin selective chaperone as it functions within the ubiquitin and/or proteasome pathway. p97 does not interact with ubiquitinated substrates on its own, but requires specific adapters that interact with ubiquitinated substrates and p97 and recruits p97 to substrates. One family of adapters contains a UBX domain, which has been shown with certain adapters to function as a p97-binding module. UBXD1 is a UBX domain containing protein and p97 adapter. This adapter is unique in that it does not harbor an ubiquitin association domain and binds p97 via its PUG domain (another p97 binding motif). Two isoforms of UBXD1 are produced in cells, a full-length form of approximately 54 kDa, and an alternatively spliced variant that lacks the amino-terminal translational start site, and encodes a 47 kDa protein that is derived from an internal translational initiation site. UBXD1 expression at the RNA level has been shown to trend lower in poor prognostic cancers, including those of the breast and prostate.

UniProt: Q9BZV1