FAS Antikörper
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- Target Alle FAS Antikörper anzeigen
- FAS (TNF Receptor Superfamily, Member 6 (FAS))
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Reaktivität
- Human
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Wirt
- Maus
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Klonalität
- Monoklonal
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Konjugat
- Dieser FAS Antikörper ist unkonjugiert
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Applikation
- Flow Cytometry (FACS)
- Spezifität
- Human/Rat CD95, Mr 45 kDa
- Produktmerkmale
- Mouse Anti-Human CD95-LE/AF
- Endotoxin-Niveau
- Low endotoxin
- Immunogen
- Human CD95 transfected L cells
- Klon
- DX3
- Isotyp
- IgG2a
- Top Product
- Discover our top product FAS Primärantikörper
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- Applikationshinweise
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- Applications: FC - Quality tested , IHC-PS - Reported in literature , ELISA - Reported in literature
- Working Dilutions: Flow Cytometry Purified (UNLB) antibody 1 g/106 cells FITC, BIOT, PE, APC and SPRD conjugates 10 L/106 cells For flow cytometry, the suggested use of these reagents is in a final volume of 100 L
- Kommentare
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in vivo induction of apoptosis
- Probenmenge
- 1 mL
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Konzentration
- 0.5 mg/mL
- Buffer
- 0.5 mg of purified immunoglobulin in 1.0 mL of PBS
- Konservierungsmittel
- Azide free
- Handhabung
- Each reagent is stable for the period shown on the bottle label if stored as directed.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- Aliquot and freeze the low endotoxin, azide-free product at -20 °C immediately upon receipt.
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- Target
- FAS (TNF Receptor Superfamily, Member 6 (FAS))
- Andere Bezeichnung
- CD95 (FAS Produkte)
- Hintergrund
- CD95, also known as Fas and Apo-1, is a 40-50 kDa type I transmembrane glycoprotein and a member of the tumor necrosis factor receptor superfamily. It is expressed by activated lymphocytes, monocytes, neutrophils, fibroblasts and cell lines. Fas ligand binding to CD95 induces apoptosis in activated mature lymphocytes thereby playing a role in maintaining peripheral tolerance. Crosslinking of CD95 by the monoclonal antibodies DX2 and DX3 delivers an apoptotic signal to Fas-sensitive cells, indicating that these monoclonal antibodies recognize a functional epitope of CD95.
- Pathways
- p53 Signalweg, Apoptose, Production of Molecular Mediator of Immune Response, Positive Regulation of Endopeptidase Activity
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