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GRP78 Antikörper

HSPA5 Reaktivität: Maus WB Wirt: Ratte Monoclonal 76-E6 unconjugated
Produktnummer ABIN135301
  • Target Alle GRP78 (HSPA5) Antikörper anzeigen
    GRP78 (HSPA5) (Heat Shock 70kDa Protein 5 (Glucose-Regulated Protein, 78kDa) (HSPA5))
    Reaktivität
    • 196
    • 124
    • 106
    • 36
    • 35
    • 34
    • 32
    • 30
    • 30
    • 20
    • 15
    • 5
    • 4
    • 4
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Maus
    Wirt
    • 136
    • 97
    • 7
    • 3
    • 1
    • 1
    Ratte
    Klonalität
    • 140
    • 106
    Monoklonal
    Konjugat
    • 99
    • 19
    • 16
    • 12
    • 12
    • 12
    • 9
    • 8
    • 8
    • 8
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    Dieser GRP78 Antikörper ist unkonjugiert
    Applikation
    • 213
    • 99
    • 88
    • 79
    • 77
    • 34
    • 28
    • 27
    • 26
    • 21
    • 13
    • 7
    • 6
    • 3
    • 3
    • 3
    • 2
    • 1
    Western Blotting (WB)
    Spezifität
    Mouse BiP, Mr 78 kDa
    Produktmerkmale
    Rat Anti-Mouse BiP-UNLB
    Aufreinigung
    Purified
    Immunogen
    Mouse BiP: chain complexes
    Klon
    76-E6
    Isotyp
    IgG2a
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    Discover our top product HSPA5 Primärantikörper
  • Applikationshinweise
    • Applications: WB - Quality tested , IP - Reported in literature , ELISA - Reported in literature
    • Working Dilutions: Immunoblotting Purified (UNLB) antibody 5 g/mL BIOT conjugate 5 g/mL
    Probenmenge
    1 mL
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Konzentration
    0.5 mg/mL
    Buffer
    0.5 mg of purified immunoglobulin in 1.0 mL of borate buffered saline,  pH 8.2. No preservatives or amine-containing buffer salts added
    Konservierungsmittel
    Without preservative
    Handhabung
    Each reagent is stable for the period shown on the bottle label if stored as directed.
    Lagerung
    4 °C
    Informationen zur Lagerung
    Store at 2-8°C
  • Target
    GRP78 (HSPA5) (Heat Shock 70kDa Protein 5 (Glucose-Regulated Protein, 78kDa) (HSPA5))
    Andere Bezeichnung
    BiP (HSPA5 Produkte)
    Hintergrund
    The immunoglobulin heavy chain binding protein BiP (Binding Protein) is a member of the hsp70 family of heat shock proteins, and is identical to the glucose regulated protein grp78.2 While BiP was originally described for its function in B cells, it is now known to be distributed in a variety of tissues, if not ubiquitous. The highly conserved hsp 70 proteins have an essential physiological role in stress responses and as molecular chaperones, which are responsible for a variety of functions such as protein transport, prevention of protein toxicity and direction of protein folding.1-5 With regard to its immunological role, BiP is a component of the endoplasmic reticulum and binds free intracellular heavy chains in nonsecreting pre-B cell lines (+,L-) or incompletely assembled Ig precursors in H+L+ secreting hybridomas and myelomas. In the absence of light chain synthesis, heavy chains remain associated with BiP and are not secreted. BiP is an ATP binding protein and the dissociation of the BiP-heavy chain complex is probably driven by the ATPase activity attributed to BiP.7
    Pathways
    Thyroid Hormone Synthesis, ER-Nucleus Signaling
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