CD22 Antikörper

Produktnummer ABIN135163

Dieser Ratte Monoklonal Antikörper detektiert spezifisch CD22 in FACS, IP, ICC, IHC (p), IHC (fro) und Act. Es zeigt Reaktivität gegenüber Proben von Maus.

Kurzübersicht für CD22 Antikörper (ABIN135163)

Target: CD22 (CD22 Molecule (CD22))

Reaktivität: Maus

Wirt: Ratte

Klonalität: Monoklonal

Konjugat: Dieser CD22 Antikörper ist unkonjugiert

Applikation: Flow Cytometry (FACS), Immunoprecipitation (IP), Immunocytochemistry (ICC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Activation (Act)

Klon: 2D6

Produktdetails anti-CD22 Antikörper

Verwendungszweck: Rat Anti-Mouse CD22-LE/AF

Spezifität: Mouse CD22, Mr 150 kDa

Produktmerkmale: Low Endotoxin/Azide Free Anti-Mouse CD22 antibody for use in flow cytometry, immunohistochemistry / immunocytochemistry, immunoprecipitation, and activation assays.

Endotoxin-Niveau: Low Endotoxin

Immunogen: Splenic lymphocyte plasma membranes from CBA x C57 F1 mice

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.5 mg/mL

Buffer: Phosphate buffered saline, pH 7.4

Konservierungsmittel: Azide free

Handhabung: Each reagent is stable for the period shown on the bottle label if stored as directed.

Lagerung: 4 °C

Informationen zur Lagerung: 2-8°C

Details zu CD22

Target: CD22 (CD22 Molecule (CD22))

Andere Bezeichnung: CD22

Hintergrund: CD22, also known as Lyb-8, is a heterodimeric transmembrane glycoprotein and a member of a structurally related group of immunoglobulin (Ig) superfamily domain-containing proteins called the sialoadhesin family. It is detected in the cytoplasm early in B cell development (late pro-B cell stage), appears on the cell surface concomitant with IgD, and is found on most IgM+IgD+ mature B lymphocytes. Expression is lost with terminal differentiation of B cells and is absent on plasma cells. Activation of B cells via cross-linking of surface Ig increases CD22 expression. CD22 associates with the B cell receptor (BCR) complex and mediates intercellular adhesion. Its intracellular domain is phosphorylated after antigen receptor cross-linking and is involved in negative regulation of B-cell activation.

Gen-ID: 12483

UniProt: P35329