VCAM1 Antikörper

Produktnummer ABIN135074

Es sind 2+ Publikationen für dieses Produkt verfügbar. Der Ratte Monoklonal anti-VCAM1 Antikörper wird verwendet zum Nachweis von VCAM1 in Proben von Maus. Er wurde validiert für WB, FACS, IP, IHC (fro), BR und Adh Act.

Kurzübersicht für VCAM1 Antikörper (ABIN135074)

Target: VCAM1 (Vascular Cell Adhesion Molecule 1 (VCAM1))

Reaktivität: Maus

Wirt: Ratte

Klonalität: Monoklonal

Konjugat: Dieser VCAM1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Flow Cytometry (FACS), Immunoprecipitation (IP), Immunohistochemistry (Frozen Sections) (IHC (fro)), Blocking Reagent (BR), Adhesion Activation (Adh Act)

Klon: M-K-2

Produktdetails anti-VCAM1 Antikörper

Verwendungszweck: Rat Anti-Mouse CD106-LE/AF

Spezifität: Mouse CD106, Mr 100-110 kDa

Produktmerkmale: Low Endotoxin/Azide Free Anti-Mouse CD106 antibody for use in flow cytometry, immunohistochemistry, western blotting, immunoprecipitation, blocking, and adhesion assays.

Endotoxin-Niveau: Low Endotoxin

Immunogen: BALB/3T3 and +/+2.4 cells

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.5 mg/mL

Buffer: Phosphate buffered saline, pH 7.4

Konservierungsmittel: Azide free

Handhabung: Each reagent is stable for the period shown on the bottle label if stored as directed.

Lagerung: 4 °C

Informationen zur Lagerung: 2-8°C

Referenzen für anti-VCAM1 Antikörper (ABIN135074)

Gilchrist, Kinchesh, Zarghami, Khrapitchev, Sibson, Kersemans, Smart: "Improved detection of molecularly targeted iron oxide particles in mouse brain using B0 field stabilised high resolution MRI." in: Magnetic resonance imaging, Vol. 67, pp. 101-108, (2020) (PubMed).

Zarghami, Khrapitchev, Perez-Balderas, Soto, Larkin, Bau, Sibson: "Optimization of molecularly targeted MRI in the brain: empirical comparison of sequences and particles." in: International journal of nanomedicine, Vol. 13, pp. 4345-4359, (2018) (PubMed).

Details zu VCAM1

Target: VCAM1 (Vascular Cell Adhesion Molecule 1 (VCAM1))

Andere Bezeichnung: CD106

Hintergrund: VCAM-1 is an adhesion molecule and a major mediator of the inflammatory response. It is expressed on activated microvascular endothelial cells in response to signals arising from immune responses in infection, graft rejection, tumor recognition and killing. The complementary binding ligand for VCAM-1 is VLA-4/CD49d. In addition to VCAM-1, VLA-4 also recognizes the extracellular matrix molecule fibronectin. This pairing of VCAM-1 and VLA-4 is able to provide a second signal (i.e., non-antigen specific) for T cell stimulation, such as that seen in transplantation. The monoclonal antibody MK-2 has been used in transplant studies to suppress cardiac rejection and induce long-term cardiac graft survival. In addition to inflammatory responses, VCAM-1 has a significant role in hemopoiesis through its ability to retain lymphocyte and myeloid precursors on stromal cells in the marrow and lymphoid organs. CD106/VCAM-1 exists as an integral membrane protein.

Gen-ID: 22329

UniProt: P29533

Pathways: Carbohydrate Homeostasis