VCAM1 Antikörper

Produktnummer ABIN135070

Dieses Ratte Monoklonal-Antikörper erkennt spezifisch VCAM1 in FACS. Er zeigt eine Reaktivität gegenüber Maus und wurde in 3+ Publikationen erwähnt.

Kurzübersicht für VCAM1 Antikörper (ABIN135070)

Target: VCAM1 (Vascular Cell Adhesion Molecule 1 (VCAM1))

Reaktivität: Maus

Wirt: Ratte

Klonalität: Monoklonal

Konjugat: Dieser VCAM1 Antikörper ist unkonjugiert

Applikation: Flow Cytometry (FACS)

Klon: M-K-2

Produktdetails anti-VCAM1 Antikörper

Spezifität: Mouse CD106, Mr 100-110 kDa

Produktmerkmale: Rat Anti-Mouse CD106-UNLB

Aufreinigung: Purified

Immunogen: BALB/3T3 and +/+2.4 cells

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise:

• Applications: FC - Quality tested , IHC-FS - Reported in literature , IP - Reported in literature , WB - Reported in literature , Adhesion - Reported in literature , Block - Reported in literature
• Working Dilutions: Flow Cytometry FITC and BIOT conjugates 1 g/106 cells PE conjugate 0.2 g/106 cells For flow cytometry, the suggested use of these reagents is in a final volume of 100 L

Probenmenge: 1 mL

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.5 mg/mL

Buffer: 0.5 mg of purified immunoglobulin in 1.0 mL of borate buffered saline,  pH 8.2. No preservatives or amine-containing buffer salts added

Konservierungsmittel: Without preservative

Handhabung: Each reagent is stable for the period shown on the bottle label if stored as directed.

Lagerung: 4 °C

Informationen zur Lagerung: Store at 2-8°C

Referenzen für anti-VCAM1 Antikörper (ABIN135070)

Wang, Cao, Gorshkov, Zhou, Yang, Xu, Ma, Zhang, Wang, Mao, Zeng, Su, Verin, Hong, Liu, Huo: "Ablation of endothelial Pfkfb3 protects mice from acute lung injury in LPS-induced endotoxemia." in: Pharmacological research, Vol. 146, pp. 104292, (2020) (PubMed).

Xu, Wang, Yan, Yang, Zhou, Zeng, Liu, An, Toque, Dong, Jiang, Fulton, Weintraub, Li, Bagi, Hong, Boison, Wu, Huo: "Regulation of endothelial intracellular adenosine via adenosine kinase epigenetically modulates vascular inflammation." in: Nature communications, Vol. 8, Issue 1, pp. 943, (2018) (PubMed).

Siler, Berlow, Kukino, Davis, Nelson, Grafe, Ono, Cetas, Pike, Alkayed: "Soluble Epoxide Hydrolase in Hydrocephalus, Cerebral Edema, and Vascular Inflammation After Subarachnoid Hemorrhage." in: Stroke, Vol. 46, Issue 7, pp. 1916-22, (2015) (PubMed).

Details zu VCAM1

Target: VCAM1 (Vascular Cell Adhesion Molecule 1 (VCAM1))

Andere Bezeichnung: CD106

Hintergrund: VCAM-1 is an adhesion molecule and a major mediator of the inflammatory response. It is expressed on activated microvascular endothelial cells in response to signals arising from immune responses in infection, graft rejection, tumor recognition and killing. The complementary binding ligand for VCAM-1 is VLA-4/CD49d. In addition to VCAM-1, VLA-4 also recognizes the extracellular matrix molecule fibronectin. This pairing of VCAM-1 and VLA-4 is able to provide a second signal (i.e., non-antigen specific) for T cell stimulation, such as that seen in transplantation. The monoclonal antibody MK-2 has been used in transplant studies to suppress cardiac rejection and induce long-term cardiac graft survival. In addition to inflammatory responses, VCAM-1 has a significant role in hemopoiesis through its ability to retain lymphocyte and myeloid precursors on stromal cells in the marrow and lymphoid organs. CD106/VCAM-1 exists as an integral membrane protein.

Pathways: Carbohydrate Homeostasis