HCN4 Antikörper (AA 1019-1108)

Produktnummer ABIN1304702

Der Maus Monoklonal Anti-HCN4-Antikörper wurde für WB, IHC und ICC validiert. Er ist geeignet, HCN4 in Proben von Ratte zu detektieren.

Kurzübersicht für HCN4 Antikörper (AA 1019-1108) (ABIN1304702)

Target: HCN4 (Hyperpolarization Activated Cyclic Nucleotide-Gated Potassium Channel 4 (HCN4))

Reaktivität: Ratte

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser HCN4 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC)

Klon: N114-10

Produktdetails anti-HCN4 Antikörper

Bindungsspezifität: AA 1019-1108

Spezifität: No off-targets reported for other HCN's

Kreuzreaktivität: Wüstenrennmaus, Human, Maus, Schwein, Ratte

Produktmerkmale:

Description: Our Anti-HCN4 mouse monoclonal primary antibody is produced in-house from hybridoma clone N114/10. It detects human, mouse, and rat HCN4, and is purified by Protein A chromatography. It is great for use in IHC, ICC, WB.

Manufacturer Comment: We produce our HCN4 mouse monoclonal primary antibody from hybridoma clone N114/10. It is great in IHC, ICC, WB and is purified by Protein A chromatography.

Aufreinigung: Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography.

Reinheit: > 90% specific antibody

Immunogen: Fusion protein amino acids 1019-1108 (cytoplasmic C-terminus) of rat HCN4 (accession number Q9JKA7) produced recombinantly in E. Coli

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise:

Dilution Range: IHC: 1:200

Dilution Range: ICC: 1:200

Dilution Range: WB: 1:500

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: 10 mM Tris, 50 mM Sodium Chloride, 0.065 % Sodium Azide pH 7.4

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Haltbarkeit: 24 months

Details zu HCN4

Target: HCN4 (Hyperpolarization Activated Cyclic Nucleotide-Gated Potassium Channel 4 (HCN4))

Andere Bezeichnung: HCN4

Hintergrund:

Synonyms: Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4

Target Description: HCN4 is a member of the hyperpolarization-activated cyclic nucleotide gated channel family, also known as pacemaker channels. This family has a role in rhythmic activity of the heart and firing neurons. HCN channels are made up of four subunits, HCN1-4 and can be formed in multiple combinations. HCN4 is found in the cell membrane as a multi pass membrane protein in the sino-atrial node of the heart. This protein is highly expressed in neurons in the thalamus and other brain regions and testis. Mutations in HCN4 have been found in several types of sinus bradycardia.

Gene Name Alternatives: HCN4

Molekulargewicht: 130 kDa

UniProt: Q9JKA7