GABBR2 Antikörper (AA 861-912)

Produktnummer ABIN1304654

Der Maus Monoklonal Anti-GABBR2-Antikörper wurde für WB, IHC und ICC validiert. Er ist geeignet, GABBR2 in Proben von Ratte zu detektieren.

Kurzübersicht für GABBR2 Antikörper (AA 861-912) (ABIN1304654)

Target: GABBR2 (gamma-aminobutyric Acid (GABA) B Receptor, 2 (GABBR2))

Reaktivität: Ratte

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser GABBR2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC)

Klon: N81-2

Produktdetails anti-GABBR2 Antikörper

Bindungsspezifität: AA 861-912

Spezifität: No off-targets reported for GABABR1

Kreuzreaktivität: Human, Maus

Produktmerkmale:

Description: Our Anti-GABA(B)R2 mouse monoclonal primary antibody is produced in-house from hybridoma clone N81/2. It is KO validated, detects human and mouse GABA(B)R2, and is purified by Protein A chromatography. It is great for use in IHC, ICC, WB.

Manufacturer Comment: We produce our GABA(B)R2 mouse monoclonal primary antibody from hybridoma clone N81/2. It is great in IHC, ICC, WB and is purified by Protein A chromatography.

Aufreinigung: Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography.

Reinheit: > 90% specific antibody

Immunogen: Fusion protein amino acids 861-912 of rat GABABR2 (accession number NP_113990) produced recombinantly in E. Coli

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: 10 mM Tris, 50 mM Sodium Chloride, 0.065 % Sodium Azide pH 7.4

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Haltbarkeit: 24 months

Details zu GABBR2

Target: GABBR2 (gamma-aminobutyric Acid (GABA) B Receptor, 2 (GABBR2))

Andere Bezeichnung: GABA R2

Hintergrund:

Synonyms: Gamma-aminobutyric acid type B receptor subunit 2 (GABA-B receptor 2) (GABA-B-R2) (GABA-BR2) (GABABR2) (Gb2) (G-protein coupled receptor 51) (HG20)

Target Description: Gamma-aminobutyric acid type B receptor subunit 2 or GABA BR2 is encoded by the gene GABBR2. GABA BR2 is a subunit of the G-protein coupled receptor for the neurotransmitter GABA (gamma-aminobutyric acid). It will inhibit neuronal activity through G protein-coupled second-messenger systems, which regulate the release of neurotransmitters and the activity of ion channels and adenylyl cyclase. GABA BR2 is highly expressed in brain, especially in cerebral cortex, thalamus, hippocampus at the cell junction, synapse, the postsynaptic cell membrane and cytoplasmic vesicle membrane. It is weakly expressed in heart, testis and skeletal muscle. Diseases associated with GABBR2 include Neurodevelopmental Disorder With Poor Language And Loss Of Hand Skills, Rett syndrome- and Early Infantile Epileptic Encephalopathy 59.

Gene Name Alternatives: GABBR2 GPR51 GPRC3B

Molekulargewicht: 105 kDa

UniProt: O75899

Pathways: cAMP Metabolic Process