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LIME Antikörper (Lck Interacting Transmembrane Adaptor 1) AA 86-202 Primary Antibody

LIME1 Reaktivität: Maus IP, WB Wirt: Maus Monoclonal mLIME-05 unconjugated
Produktnummer ABIN1302445
$417.45
Zzgl. Versandkosten $45.00
0.1 mg
local_shipping Lieferung nach: Vereinigte Staaten von Amerika
Lieferung in 5 bis 7 Werktagen
  • Target Alle LIME (LIME1) Antikörper anzeigen
    LIME (LIME1)
    Bindungsspezifität
    • 17
    • 10
    • 7
    • 6
    • 4
    • 2
    • 1
    • 1
    • 1
    AA 86-202
    Reaktivität
    • 32
    • 8
    Maus
    Wirt
    • 24
    • 9
    • 7
    Maus
    Klonalität
    • 32
    • 8
    Monoklonal
    Konjugat
    • 16
    • 6
    • 4
    • 4
    • 4
    • 3
    • 3
    Dieser LIME Antikörper ist unkonjugiert
    Applikation
    • 31
    • 24
    • 4
    • 4
    • 2
    • 2
    • 1
    Immunoprecipitation (IP), Western Blotting (WB)
    Spezifität
    Mouse monoclonal antibody mLIME-05 reacts with the cytoplasmic domain of LIME, a 30 kDa Lck-interacting transmembrane adaptor expressed mainly by T cells.
    Kreuzreaktivität (Details)
    Mouse, Other not tested
    Aufreinigung
    Purified by protein-A affinity chromatography
    Reinheit
    > 95 % (by SDS-PAGE)
    Immunogen
    Recombinant protein corresponding to amino acids 86-202 of mouse LIME
    Klon
    MLIME-05
    Isotyp
    IgG2a
  • Applikationshinweise
    Optimal working dilution should be determined by the investigator.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Konzentration
    1 mg/mL
    Buffer
    Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.4
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handhabung
    Do not freeze.
    Lagerung
    4 °C
    Informationen zur Lagerung
    Store at 2-8°C. Do not freeze. Do not use after expiration date stamped on vial label.
  • Target
    LIME (LIME1)
    Andere Bezeichnung
    LIME (LIME1 Produkte)
    Synonyme
    LIME1, DKFZp459A158, LIME, LP8067, dJ583P15.4, 2810038K19Rik, RGD1562795, Lck interacting transmembrane adaptor 1, LIME1, Lime1
    Hintergrund
    LIME (Lck-interacting molecule) is a 30 kDa double-palmitoylated protein with unusually basic cytoplasmic domain, expressed by T cells. After ligation of CD4 or CD8 T cell coreceptors, LIME is phosphorylated by Src-family kinases and associates with Lck and Fyn kinases and with their negative regulator Csk. Interestingly, Csk-mediated phosphorylation of C-terminal negative-regulatory tyrosine of LIME-associated Lck can result in increase of enzymatic activity compared with the total pool of Lck, thus, LIME serves as a positive regulator of TCR-dependent T cell signaling. However, under some circumstances, LIME may mediate inhibitory signals.
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