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ABCB1 Antikörper (ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1) Internal Region Primary Antibody

ABCB1 Reaktivität: Human, Maus, Ratte, Hund, Affe ELISA, WB Wirt: Kaninchen Polyclonal unconjugated
Pubmed (1 reference)
Produktnummer ABIN129711
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  • Target Alle ABCB1 Antikörper anzeigen
    ABCB1
    Bindungsspezifität
    • 6
    • 6
    • 4
    • 4
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Internal Region
    Reaktivität
    • 66
    • 16
    • 12
    • 8
    • 4
    • 4
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Human, Maus, Ratte, Hund, Affe
    Wirt
    • 45
    • 28
    Kaninchen
    Klonalität
    • 44
    • 29
    Polyklonal
    Konjugat
    • 49
    • 4
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser ABCB1 Antikörper ist unkonjugiert
    Applikation
    • 40
    • 27
    • 26
    • 22
    • 18
    • 16
    • 13
    • 12
    • 4
    • 2
    • 2
    • 2
    • 2
    • 1
    ELISA, Western Blotting (WB)
    Spezifität
    This affinity-purified antibody is directed against human ABCB1 protein. The product was affinity purified from monospecific antiserum by immunoaffinity chromatography. A BLAST analysis was used to suggest cross reactivity with ABCB1 protein from human, monkey, dog, mouse, and rat based on 100% homology with the immunizing sequence. Reactivity against homologues from other sources is not known.
    Produktmerkmale
    ATP-Binding Cassette Sub-Family B Member 1 (ABCB1, also named P-glycoprotein) is a plasma membrane-associated multidrug transporter that utilizes the energy of ATP hydrolysis to pump toxic xenobiotics out of cells. Unique features of ABCB1 are its very broad substrate specificity and its basal ATPase activity in the absence of transport substrates. Human ABCB1 plays an important role in absorption, distribution, metabolism, excretion and toxicity of pharmacologically relevant drugs. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anti-cancer drugs. This protein also functions as a transporter across the blood-brain barrier.
    Aufreinigung
    affinity purified
    Sterilität
    Sterile filtered
    Immunogen
    This affinity purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to amino acids 262-277 of human ABCB1 protein.
    Immunogen Type: Peptide
    Isotyp
    IgG
  • Applikationshinweise
    This affinity purified antibody has been tested for use in ELISA and western blot.
    Kommentare

    Gene Name: ABCB1

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1.0 mg/mL
    Buffer
    0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
    Vorsichtsmaßnahmen
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C/-20 °C
    Informationen zur Lagerung
    Store vial at 4 °C prior to restoration. For extended storage aliquot contents and freeze at -20 °C or below. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4 °C as an undiluted liquid. Dilute only prior to immediate use. Expiration date is one (1) year from date of opening.
    Haltbarkeit
    12 months
  • Al-Shawi, Omote: "The remarkable transport mechanism of P-glycoprotein: a multidrug transporter." in: Journal of bioenergetics and biomembranes, Vol. 37, Issue 6, pp. 489-96, (2006) (PubMed).

  • Target
    ABCB1
    Andere Bezeichnung
    ABCB1 (ABCB1 Produkte)
    Synonyme
    ABC20, CD243, CLCS, GP170, MDR1, P-GP, PGY1, Abcb1, Mdr1a, p-gp, xemdr, Mdr1, Mdr1b, Pgy-1, Pgy1, mdr, ABCB1, PGP1, ATP binding cassette subfamily B member 1, ATP binding cassette subfamily B member 1A, ATP binding cassette subfamily B member 1 L homeolog, ATP-binding cassette, sub-family B (MDR/TAP), member 1B, ABCB1, Abcb1a, abcb1.L, Abcb1b, Abcb1
    Hintergrund
    ATP-Binding Cassette Sub-Family B Member 1 (ABCB1, also named P-glycoprotein) is a plasma membrane-associated multidrug transporter that utilizes the energy of ATP hydrolysis to pump toxic xenobiotics out of cells. Unique features of ABCB1 are its very broad substrate specificity and its basal ATPase activity in the absence of transport substrates. Human ABCB1 plays an important role in absorption, distribution, metabolism, excretion and toxicity of pharmacologically relevant drugs. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anti-cancer drugs. This protein also functions as a transporter across the blood-brain barrier.
    Synonyms: ATP binding cassette sub family B MDR/TAP member 1 antibody, CD243 antibody, CD243 antigen antibody, CLCS antibody, GP170 antibody, MDR 1 antibody
    Gen-ID
    340273, 42741659
    UniProt
    Q2M3G0
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