ABCB1 Antikörper (ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1) Internal Region

Produktnummer ABIN129711

Produktdetails anti-ABCB1 Antikörper

Target: ABCB1

Bindungsspezifität: Internal Region

Reaktivität: Human, Maus, Ratte, Hund, Affe

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ABCB1 Antikörper ist unkonjugiert

Applikation: ELISA, Western Blotting (WB)

Spezifität: This affinity-purified antibody is directed against human ABCB1 protein. The product was affinity purified from monospecific antiserum by immunoaffinity chromatography. A BLAST analysis was used to suggest cross reactivity with ABCB1 protein from human, monkey, dog, mouse, and rat based on 100% homology with the immunizing sequence. Reactivity against homologues from other sources is not known.

Produktmerkmale: ATP-Binding Cassette Sub-Family B Member 1 (ABCB1, also named P-glycoprotein) is a plasma membrane-associated multidrug transporter that utilizes the energy of ATP hydrolysis to pump toxic xenobiotics out of cells. Unique features of ABCB1 are its very broad substrate specificity and its basal ATPase activity in the absence of transport substrates. Human ABCB1 plays an important role in absorption, distribution, metabolism, excretion and toxicity of pharmacologically relevant drugs. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anti-cancer drugs. This protein also functions as a transporter across the blood-brain barrier.

Aufreinigung: affinity purified

Sterilität: Sterile filtered

Immunogen: This affinity purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to amino acids 262-277 of human ABCB1 protein.
Immunogen Type: Peptide

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: This affinity purified antibody has been tested for use in ELISA and western blot.

Kommentare:

Gene Name: ABCB1

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1.0 mg/mL

Buffer: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store vial at 4 °C prior to restoration. For extended storage aliquot contents and freeze at -20 °C or below. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4 °C as an undiluted liquid. Dilute only prior to immediate use. Expiration date is one (1) year from date of opening.

Haltbarkeit: 12 months

Referenzen für anti-ABCB1 Antikörper (ABIN129711)

Al-Shawi, Omote: "The remarkable transport mechanism of P-glycoprotein: a multidrug transporter." in: Journal of bioenergetics and biomembranes, Vol. 37, Issue 6, pp. 489-96, (2006) (PubMed).

Details zu ABCB1

Target: ABCB1

Andere Bezeichnung: ABCB1 (ABCB1 Produkte)

Synonyme: ABC20, CD243, CLCS, GP170, MDR1, P-GP, PGY1, Abcb1, Mdr1a, p-gp, xemdr, Mdr1, Mdr1b, Pgy-1, Pgy1, mdr, ABCB1, PGP1, ATP binding cassette subfamily B member 1, ATP binding cassette subfamily B member 1A, ATP binding cassette subfamily B member 1 L homeolog, ATP-binding cassette, sub-family B (MDR/TAP), member 1B, ABCB1, Abcb1a, abcb1.L, Abcb1b, Abcb1

Hintergrund: ATP-Binding Cassette Sub-Family B Member 1 (ABCB1, also named P-glycoprotein) is a plasma membrane-associated multidrug transporter that utilizes the energy of ATP hydrolysis to pump toxic xenobiotics out of cells. Unique features of ABCB1 are its very broad substrate specificity and its basal ATPase activity in the absence of transport substrates. Human ABCB1 plays an important role in absorption, distribution, metabolism, excretion and toxicity of pharmacologically relevant drugs. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anti-cancer drugs. This protein also functions as a transporter across the blood-brain barrier.
Synonyms: ATP binding cassette sub family B MDR/TAP member 1 antibody, CD243 antibody, CD243 antigen antibody, CLCS antibody, GP170 antibody, MDR 1 antibody

Gen-ID: 340273, 42741659

UniProt: Q2M3G0