SPRY4 Antikörper (Sprouty RTK Signaling Antagonist 4) AA 306-322

Produktnummer ABIN129626

Produktdetails anti-SPRY4 Antikörper

Target: SPRY4

Bindungsspezifität: AA 306-322

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SPRY4 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC), ELISA, Western Blotting (WB)

Kreuzreaktivität: Schimpanse

Produktmerkmale: Concentration Definition: by UV absorbance at 280 nm

Immunogen: This affinity purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to amino acids 306-322 of Human Sprouty-4 protein.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: This affinity purified antibody has been tested for use in ELISA, immunohistochemistry and western blot.  Specific conditions for reactivity should be optimized by the end user. Expect a band (maybe a doublet) ~35 kDa in size corresponding to Sprouty-4 by western blotting in the appropriate cell lysate or extract.  Some non-specific banding may be observed using this antibody.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1.1 mg/mL

Buffer: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Details zu SPRY4

Target: SPRY4

Andere Bezeichnung: Sprouty-4 (SPRY4 Produkte)

Synonyme: SPRY4, LOC100218545, HH17, A030006O18Rik, sprouty4, sprouty RTK signaling antagonist 4, sprouty (Drosophila) homolog 4, sprouty homolog 4 (Drosophila), Spry4, SPRY4, spry4

Hintergrund: Sprouty-4 (also known as SPRY4) is an inhibitor of the insulin receptor and EGFR-transduced mitogen-activated protein kinase (MAPK) signaling pathway downstream of FGF and EGF receptor tyrosine kinase activation. It is positioned upstream of RAS activation and impairs the formation of active GTP-RAS.  SPRY4 is widely expressed, with different isoforms. The protein consists of 322 amino acids, with a cysteine-rich region, Src homology 3 binding regions, proline-rich regions, and a PEST sequence. It is expressed predominantly in the cytoplasm. Northern results show bands across most tissues, with strongest expression in heart, brain, placenta, lung, and intestine.
Synonyms: Sprouty-4, SPRY4

Gen-ID: 81848, 42741659

UniProt: P08183