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USP7 Antikörper (Ubiquitin Specific Peptidase 7 (Herpes Virus-Associated)) Primary Antibody

USP7 Reaktivität: Human ELISA, WB Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN129596
$658.50
Zzgl. Versandkosten $45.00 und $20.00 Trockeneis
100 μg
local_shipping Lieferung nach: Vereinigte Staaten von Amerika
Lieferung in 1 bis 2 Werktagen
  • Target Alle USP7 Antikörper anzeigen
    USP7
    Reaktivität
    • 103
    • 34
    • 34
    • 8
    • 6
    • 5
    • 4
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Human
    Wirt
    • 93
    • 11
    • 1
    Kaninchen
    Klonalität
    • 84
    • 21
    Polyklonal
    Konjugat
    • 49
    • 8
    • 7
    • 6
    • 4
    • 4
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser USP7 Antikörper ist unkonjugiert
    Applikation
    • 73
    • 46
    • 35
    • 15
    • 14
    • 14
    • 13
    • 7
    • 5
    • 4
    • 3
    • 3
    • 2
    • 1
    • 1
    ELISA, Western Blotting (WB)
    Produktmerkmale
    Concentration Definition: by UV absorbance at 280 nm
    Immunogen
    This affinity purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to amino acids near the amino terminus of human HAUSP protein.
    Isotyp
    IgG
  • Applikationshinweise
    This affinity purified antibody has been tested for use in ELISA and western blot.  Specific conditions for reactivity should be optimized by the end user.  Expect a band approximately 130 kDa in size corresponding to HAUSP protein by western blotting in the appropriate cell lysate or extract.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    0.98 mg/mL
    Buffer
    0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
    Vorsichtsmaßnahmen
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C
  • Target
    USP7
    Andere Bezeichnung
    HAUSP (USP7 Produkte)
    Synonyme
    CG1490, Dmel\\CG1490, USP7, 2210010O09Rik, AA409944, AA617399, AU019296, AW548146, C80752, Hausp, HAUSP, TEF1, UBP, Ubiquitin-specific protease 7, ubiquitin carboxyl-terminal hydrolase 7, ubiquitin specific peptidase 7, Usp7, LOC100201254, USP7
    Hintergrund
    HAUSP (also known as deubiquitinating enzyme 7, herpes virus associated ubiquitin specific protease, TEF1, ubiquitin carboxyl terminal hydrolase 7, ubiquitin specific protease 7, ubiquitin thiolesterase 7, and USP7) is a novel p53 interacting protein. HAUSP was identified by mass spectrometry of affinity purified p53 associated factors by Li et al. HAUSP strongly stabilizes p53, even in the presence of excess MDM2, and also induces p53-dependent cell growth repression and apoptosis. HAUSP has an intrinsic enzymatic activity that specifically de-ubiquitinates p53 both in vivo and in vitro. Expression of a catalytically inactive point mutation of HAUSP in cells increased the levels of p53 ubiquitination and also destabilized p53. Li et al concluded that their findings revealed an important mechanism by which p53 can be stabilized by direct de-ubiquitination and also implied that HAUSP may function as a tumor suppressor in vivo through the stabilization of p53.
    Synonyms: Deubiquitinating enzyme 7 antibody, herpes virus associated antibody, Herpes virus associated ubiquitin specific protease antibody, TEF 1 antibody, tef-1 antibody, TEF1 antibody, Ubiquitin carboxyl terminal hydrolase 7 antibody
    Gen-ID
    7874, 150378533
    UniProt
    Q93009
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