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RFFL Antikörper (Ring Finger and FYVE-Like Domain Containing 1) AA 1-363 Primary Antibody

RFFL Reaktivität: Human IHC, ELISA, WB Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN129535
$744.00
Zzgl. Versandkosten $45.00
500 μg
local_shipping Lieferung nach: Vereinigte Staaten von Amerika
Lieferung in 1 bis 2 Werktagen
  • Target Alle RFFL Antikörper anzeigen
    RFFL
    Bindungsspezifität
    • 16
    • 15
    • 8
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    AA 1-363
    Reaktivität
    • 46
    • 22
    • 6
    • 4
    • 4
    • 3
    • 3
    • 3
    • 2
    Human
    Wirt
    • 43
    • 3
    Kaninchen
    Klonalität
    • 44
    • 2
    Polyklonal
    Konjugat
    • 18
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser RFFL Antikörper ist unkonjugiert
    Applikation
    • 32
    • 22
    • 13
    • 13
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    Immunohistochemistry (IHC), ELISA, Western Blotting (WB)
    Produktmerkmale
    Concentration Definition: by UV absorbance at 280 nm
    Immunogen
    This affinity purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a recombinant protein corresponding to amino acids 1-363 of human RFFL protein.
    Immunogentype:Recombinant
    Isotyp
    IgG
  • Applikationshinweise
    This protein A purified antibody has been tested for use in ELISA, immunohistochemistry and western blot.  Specific conditions for reactivity should be optimized by the end user. Expect a band approximately 41 kDa in size corresponding to RFFL protein by western blotting in the appropriate tissue or cell lysate or extract.  Isoforms 2 and 3 are 39.7 and 36.6 kDa, respectively and should also cross react with this antibody.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Lyophilized
    Rekonstitution
    Restore with deionized water (or equivalent)
    Konzentration
    5.0 mg/mL
    Buffer
    0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
    Vorsichtsmaßnahmen
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C
  • Target
    RFFL
    Andere Bezeichnung
    RFFL (RFFL Produkte)
    Synonyme
    MGC84042, RFFL, Rffl, 1700051E09Rik, 4930516L10Rik, BG080975, Carp2, CARP-2, CARP2, FRING, RIFIFYLIN, RNF189, RNF34L, ring finger and FYVE like domain containing E3 ubiquitin protein ligase, ring finger and FYVE-like domain containing E3 ubiquitin protein ligase L homeolog, ring finger and FYVE-like domain containing 1, ring finger and FYVE like domain containing protein, ring finger and FYVE-like domain containing E3 ubiquitin protein ligase, RFFL, rffl.L, Rffl
    Hintergrund
    This antibody is designed, produced, and is suitable for Cancer, Immunology and Nuclear Signaling research. RFFL, also known as Rififylin, RING finger and FYVE-like domain-containing protein 1, FYVE-RING finger protein, Sakura, Fring, Caspases-8 and -10-associated RING finger protein 2, CARP-2, Caspase regulator CARP2, RING finger protein 189 and RING finger protein 34-like, is a novel modulator of NF-kB activation.  RFFL possesses E3 ubiquitin protein ligase activity and has been shown to regulate the levels of CASP8 and CASP10 by targeting them for proteasomal degradation. RFFL also possesses anti-apoptotic activity and may bind phosphatidylinositol phosphates. RFFL is a membrane bound cytoplasmic protein that is expressed ubiquitously. RFFL can be detected in spleen, thymus, prostate, testis, ovary, small intestine, colon and peripheral blood leukocytes and is rapidly degraded after stimulation with TNFSF10, and probably by caspases. Multiple transcript variants have been detected for this protein.
    Synonyms: RFFL, Rififylin, RING finger and FYVE-like domain-containing protein 1, FYVE-RING finger protein, Sakura, Fring, Caspases-8 and -10-associated RING finger protein 2, CARP-2, Caspase regulator CARP2, RING finger protein 189 and RING finger protein 34-like
    Gen-ID
    117584, 17432433
    UniProt
    Q8WZ73
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