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NRF1 Antikörper (Nuclear Respiratory Factor 1) AA 1 Primary Antibody

NRF1 Reaktivität: Maus IHC, ELISA, WB Wirt: Kaninchen Polyclonal unconjugated
Pubmed (3 references)
Produktnummer ABIN129526
$744.00
Zzgl. Versandkosten $45.00 und $20.00 Trockeneis
500 μg
local_shipping Lieferung nach: Vereinigte Staaten von Amerika
Lieferung in 1 bis 2 Werktagen
  • Target Alle NRF1 Antikörper anzeigen
    NRF1
    Bindungsspezifität
    • 15
    • 11
    • 10
    • 9
    • 7
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 1
    Reaktivität
    • 78
    • 44
    • 40
    • 5
    • 5
    • 5
    • 5
    • 4
    • 4
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    Maus
    Wirt
    • 71
    • 8
    Kaninchen
    Klonalität
    • 64
    • 15
    Polyklonal
    Konjugat
    • 44
    • 5
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser NRF1 Antikörper ist unkonjugiert
    Applikation
    • 60
    • 36
    • 15
    • 15
    • 14
    • 14
    • 9
    • 8
    • 3
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    Immunohistochemistry (IHC), ELISA, Western Blotting (WB)
    Produktmerkmale
    Concentration Definition: by UV absorbance at 280 nm
    Immunogen
    This protein A purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a purified recombinant mouse NRF1 protein corresponding to - 534 of the Native
    Immunogentype:Recombinant
    Isotyp
    IgG
  • Applikationshinweise
    This protein A purified antibody has been tested for use in ELISA, immunohistochemistry and by western blot.  Specific conditions for reactivity should be optimized by the end user. Expect a band approximately 67 kDa in size corresponding to NRF1 by western blotting in the appropriate cell lysate or extract.  Splice variants exist for this protein that may result in the detection of lower molecular weight bands.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    2.3 mg/mL
    Buffer
    0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
    Vorsichtsmaßnahmen
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C
  • Hinkley, Morton, Ichinoseki-Sekine, Huertas, Smuder: "Exercise Training Prevents Doxorubicin-induced Mitochondrial Dysfunction of the Liver." in: Medicine and science in sports and exercise, Vol. 51, Issue 6, pp. 1106-1115, (2019) (PubMed).

    Miura, Saitoh, Kokubun, Owada, Yamauchi, Machii, Takeishi: "Mitochondrial-Targeted Antioxidant Maintains Blood Flow, Mitochondrial Function, and Redox Balance in Old Mice Following Prolonged Limb Ischemia." in: International journal of molecular sciences, Vol. 18, Issue 9, (2018) (PubMed).

    Joseph, Nguyen, Welter, Dominguez, Behnke, Adhihetty: "Mitochondrial adaptations evoked with exercise are associated with a reduction in age-induced testicular atrophy in Fischer-344 rats." in: Biogerontology, Vol. 15, Issue 5, pp. 517-534, (2015) (PubMed).

  • Target
    NRF1
    Andere Bezeichnung
    NRF1 (NRF1 Produkte)
    Synonyme
    ALPHA-PAL, C87038, D6Ertd415e, SC:BZ3C13.1, SC:bZ3C13.2, ube2h, Nfe2l1_retired, IBR/F, NRF1, alpha-pal, nrf-1, LOC100220087, nuclear respiratory factor 1, nuclear respiratory factor 1 S homeolog, NRF1, Nrf1, nrf1, nrf1.S
    Hintergrund
    NRF1 (also known as nuclear respiratory factor 1, alpha palindromic binding protein and alpha-pal) is the mammalian homolog to the erect wing (ewg) Drosophila protein that is required for proper development of the central nervous system and indirect flight muscles. In mammals NRF1 functions as a transcription factor that activates the expression of the EIF2S1 (EIF2-alpha) gene. This protein links the transcriptional modulation of key metabolic genes to cellular growth and development and has been implicated in the control of nuclear genes required for respiration, heme biosynthesis, and mitochondrial DNA transcription and replication.  NRF1 forms a homodimer and binds DNA as a dimer.  NRF1 shows a nuclear localization and is widely expressed in embryonic, fetal, and adult tissues.  Phosphorylation of NRF1 enhances DNA binding.  Multiple splice variants have been identified for this protein.
    Synonyms: alpha pal antibody, alpha palindromic binding protein antibody, locus control region factor 1 antibody, NFE2 related factor 1 antibody, nuclear respiratory factor 1 antibody, transcription factor 11 antibody
    Gen-ID
    18181, 13529317
    UniProt
    Q9WU00
    Pathways
    Regulation of Lipid Metabolism by PPARalpha
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