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NOXA Antikörper
PMAIP1
Reaktivität: Human, Maus, Ratte
WB
Wirt: Kaninchen
Polyclonal
unconjugated
Produktdetails anti-NOXA Antikörper
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Target
Alle NOXA (PMAIP1) Antikörper anzeigen
NOXA (PMAIP1)
(Phorbol-12-Myristate-13-Acetate-Induced Protein 1 (PMAIP1))
Reaktivität
Human, Maus, Ratte
Wirt
Alle Wirte für NOXA Antikörper
Kaninchen
Klonalität
Alle Klonalitäten für NOXA Antikörper
Polyklonal
Konjugat
Alle Konjugate für NOXA Antikörper
Dieser NOXA Antikörper ist unkonjugiert
Applikation
Alle Applikationen für NOXA Antikörper
Western Blotting (WB)
Spezifität
The antibody recognizes mainly ~16 kDa band. A ~34 kDa band is also detected to the lesser extent.
Aufreinigung
Protein A chromatography
Immunogen
Synthetic peptide surrounding amino acid 100 of human Noxa
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Anwendungsinformationen
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Applikationshinweise
Western Blot: 0.5-4 μg/mL. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Beschränkungen
Nur für Forschungszwecke einsetzbar
Handhabung
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Konzentration
0.2 mg/mL
Buffer
BPS containing 0.5 % BSA, 30 % glycerol, and 0.01 % thimerosal
Konservierungsmittel
Thimerosal (Merthiolate)
Vorsichtsmaßnahmen
This product contains thimerosal (merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handhabung
Avoid repeated freezing and thawing.
Lagerung
-20 °C
Informationen zur Lagerung
Store the antibody undiluted (in aliquots) at -20 °C to -70 °C.
Details zu NOXA
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Target
NOXA (PMAIP1)
(Phorbol-12-Myristate-13-Acetate-Induced Protein 1 (PMAIP1))
Andere Bezeichnung
NOXA (PMAIP1 Produkte )
Synonyme
TN3 antikoerper, PMAIP1 antikoerper, zgc:162379 antikoerper, APR antikoerper, NOXA antikoerper, Noxa antikoerper, phorbol-12-myristate-13-acetate-induced protein 1 antikoerper, PMAIP1 antikoerper, pmaip1 antikoerper, Pmaip1 antikoerper
Hintergrund
Noxa is a BH3-only member of the Bcl-2 family. Expression of Noxa gene involves direct activation of its promotor by p53. Increased expression of Noxa protein occurs in normal thymocytes but not in p53-deficient thymocytes. Coimmunoprecipitation data suggest that Noxa protein may interact with proteins belonging to the Bcl-2 family, such as Bcl-xL and Mcl-1. Blocking the endogenous Noxa induction results in the suppression of apoptosis. These suggest Noxa may represent a candidate mediator of p53-induced apoptosis.Synonyms: PMA-induced protein 1, PMAIP1, Phorbol-12-myristate-13-acetate-induced protein 1
Gen-ID
5366
NCBI Accession
NP_066950
UniProt
Q13794
Pathways
p53 Signalweg , Positive Regulation of Endopeptidase Activity , Regulation of Carbohydrate Metabolic Process , Positive Regulation of Response to DNA Damage Stimulus
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