FOXO4 Antikörper (pSer193)

Produktnummer ABIN127070

Produktdetails anti-FOXO4 Antikörper

Target: FOXO4 (Forkhead Box O4 (FOXO4))

Bindungsspezifität: pSer193

Reaktivität: Human, Hamster

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser FOXO4 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Spezifität: Phospho-AFX (Ser193) antibody detects only the phosphorylated Ser193 of AFX and does not react with nonphosphorylated AFX.

Aufreinigung: Peptide affinity chromatography

Anwendungsinformationen

Applikationshinweise: The antibody can be used for Western blotting (1-2 μg/mL).
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.5 mg/mL

Buffer: PBS containing 30 % glycerol, 0.5 % BSA, and 0.02 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: -20 °C

Informationen zur Lagerung: Store (in aliquots) at -20 °C. For long term storage freeze at -70 °C.

Details zu FOXO4

Target: FOXO4 (Forkhead Box O4 (FOXO4))

Andere Bezeichnung: FOXO4 / AFX1 / MLLT7 (FOXO4 Produkte)

Synonyme: FOXO4 antikoerper, foxo4 antikoerper, AFX antikoerper, AFX1 antikoerper, MLLT7 antikoerper, Afxh antikoerper, Mllt7 antikoerper, afx antikoerper, RGD1561201 antikoerper, forkhead box O4 antikoerper, forkhead box O4 L homeolog antikoerper, FOXO4 antikoerper, foxo4.L antikoerper, Foxo4 antikoerper

Hintergrund: The forkhead family of transcription factors is involved in tumorigenesis in rhabdomyosarcoma and acute leukemias. Within the family, three members (FKHR, AFX, AND FKHRL1) have sequence similarity to the nematode homolog Daf 16, recently shown to mediate signaling via a pathway involving IGFR1, P13-K and Akt. There are three potential Akt phosphorylation sites on the FKHR proteins. One site, FKHR Ser256 is found in the Forkhead domain and the other two are outside this domain. Recent studies show that phosphorylation of FKHR family members by Akt promotes cell survival. Phosphorylation regulates FKHR nuclear translocation and target gene transcription. Insulin also stimulates FKHR phosphorylation at Ser253.Synonyms: Fork head domain transcription factor AFX1, Forkhead box protein O4

Gen-ID: 4303

NCBI Accession: NP_001164402

UniProt: P98177

Pathways: Zellzyklus, Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Neurotrophin Signalübertragung, Regulation of Muscle Cell Differentiation