Cathepsin B Antikörper
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- Target Alle Cathepsin B (CTSB) Antikörper anzeigen
- Cathepsin B (CTSB)
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Reaktivität
- Human, Maus, Ratte
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser Cathepsin B Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- Spezifität
- The purified antibody detects both the proform (37-43 kDa) and the mature form (25 kDa) of Cathepsin B.
- Kreuzreaktivität (Details)
- Species reactivity (tested):Human, Mouse and Rat.
- Aufreinigung
- Affinity Chromatography.
- Immunogen
- Synthetic peptide surrounding amino acid 322 of human cathepsins B
- Top Product
- Discover our top product CTSB Primärantikörper
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- Applikationshinweise
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Western Blot: 0.5-4 μg/mL. Immunohistochemistry: 10-20 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. - Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Konzentration
- 0.2 mg/mL
- Buffer
- PBS, pH 7.2 containing 30 % Glycerol, 0.5 % BSA and 0.01 % Thimerosal.
- Konservierungsmittel
- Thimerosal (Merthiolate)
- Vorsichtsmaßnahmen
- This product contains thimerosal (merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handhabung
- Avoid repeated freezing and thawing.
- Lagerung
- -20 °C/-80 °C
- Informationen zur Lagerung
- Store the antibody undiluted at -20 °C or for long term storage (in aliquots) at -20 °C to -70 °C.
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- Target
- Cathepsin B (CTSB)
- Andere Bezeichnung
- Cathepsin B (CTSB Produkte)
- Synonyme
- APPS antikoerper, CPSB antikoerper, CB antikoerper, apps antikoerper, cpsb antikoerper, LOC692390 antikoerper, CTSB antikoerper, cathepsin B antikoerper, cathepsin B S homeolog antikoerper, CTSB antikoerper, Ctsb antikoerper, ctsb.S antikoerper, LOC692390 antikoerper
- Hintergrund
- Cathepsin B is a normal lysosomal cysteine proteinase that is expressed in all cells. It is synthesized as an inactive 43 kDa pro-enzyme which, by removal of a 62 amino acid propeptide, is activated to the single-chain form of 31 kDa or the two-chain form (25 and 5 kDa subunits). Matured cathepsin B is normally localized in the lysosomes where it functions in protein turnover. Cathepsin B is also shown capable of degrading extracellular matrix proteins. Elevated levels of cathepsin B correlate with malignancy suggesting that this enzyme may be a useful prognostic marker for several types of human cancers.Synonyms: APP secretase, APPS, CPSB, CTSB, Cathepsin B1
- Gen-ID
- 1508
- NCBI Accession
- NP_001899
- UniProt
- P07858
- Pathways
- Activation of Innate immune Response, Toll-Like Receptors Cascades
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