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beta Amyloid Antikörper (C-Term, N-Term) (FITC)

Dieses Maus Monoklonal-Antikörper erkennt spezifisch beta Amyloid in IF. Er zeigt eine Reaktivität gegenüber Human.
Produktnummer ABIN126718

Kurzübersicht für beta Amyloid Antikörper (C-Term, N-Term) (FITC) (ABIN126718)

Target

Alle beta Amyloid (Abeta) Antikörper anzeigen
beta Amyloid (Abeta) (Amyloid beta (Abeta))

Reaktivität

  • 74
  • 20
  • 14
  • 4
  • 3
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
Human

Wirt

  • 39
  • 28
  • 6
  • 2
  • 2
Maus

Klonalität

  • 42
  • 28
  • 3
Monoklonal

Konjugat

  • 68
  • 5
  • 1
  • 1
  • 1
  • 1
Dieser beta Amyloid Antikörper ist konjugiert mit FITC

Applikation

  • 52
  • 50
  • 33
  • 18
  • 17
  • 12
  • 9
  • 5
  • 5
  • 5
  • 5
  • 5
  • 4
  • 4
  • 4
  • 3
  • 3
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
Immunofluorescence (IF)

Klon

5C3
  • Bindungsspezifität

    • 17
    • 12
    • 12
    • 5
    • 5
    • 4
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 1-40, C-Term, N-Term

    Spezifität

    This antibody specifically interacts with the C-Terminus of β-Amyloid (1 - 40) and does not crossreact with β-Amyloid (1 - 42).

    Aufreinigung

    Size exclusion chromatography

    Immunogen

    C-terminal peptide conjugated to KLH

    Isotyp

    IgG1
  • Applikationshinweise

    Immunocytochemistry: 1 - 10 μg/mL.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Konzentration

    0.5 mg/mL

    Buffer

    PBS/0.09 % Na-Azide/PEG and Sucrose

    Konservierungsmittel

    Sodium azide

    Vorsichtsmaßnahmen

    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Lagerung

    4 °C/-80 °C

    Informationen zur Lagerung

    Store the antibody (aliquote in liquid nitrogen) at -80 °C. Avoid repeated freezing and thawing. Thaw aliquots at 37 °C. Thawed aliquots may be stored at 2-8 °C up to 3 months.
    Shelf life: one year from despatch.

    Haltbarkeit

    12 months
  • Target

    beta Amyloid (Abeta) (Amyloid beta (Abeta))

    Andere Bezeichnung

    Amyloid beta

    Hintergrund

    The beta-amyloid peptide (beta A4), proteolytically released from the amyloid precursor protein (APP), is the principal component of senile plaques in Alzheimer's disease. Cleavage of APP by alpha-secretase or alternatively by beta-secretase leads to generation and extracellular release of soluble APP peptides, S-APP-alpha and S-APP-beta, respectively, and the retention of corresponding membrane-anchored C-terminal fragments, C83 and C99. Subsequent processing of C83 by gamma-secretase yields P3 peptides. This is the major secretory pathway and is nonamyloidogenic. Alternatively, presenilin/nicastrin-mediated gamma-secretase processing of C99 releases the amyloid beta proteins, amyloid-beta 40 (Abeta40) and amyloid-beta 42 (Abeta42), major components of amyloid plaques, and the cytotoxic C-terminal fragments, gamma-CTF(50), gamma-CTF(57) and gamma-CTF(59).Synonyms: Amyloid beta peptide

    Pathways

    Inflammasome
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