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CD59 Antikörper (CD59) (APC) Primary Antibody

CD59 Reaktivität: Human FACS, Func, IHC (p), IP Wirt: Maus Monoclonal MEM-43 APC
Pubmed (3 references)
Produktnummer ABIN125700
$484.24
Zzgl. Versandkosten $45.00
100 tests
local_shipping Lieferung nach: Vereinigte Staaten von Amerika
Lieferung in 5 bis 7 Werktagen
  • Target Alle CD59 Antikörper anzeigen
    CD59
    Reaktivität
    • 173
    • 17
    • 13
    • 9
    • 6
    • 3
    • 2
    • 2
    • 2
    • 1
    Human
    Wirt
    • 113
    • 88
    • 6
    • 6
    Maus
    Klonalität
    • 133
    • 77
    • 1
    Monoklonal
    Konjugat
    • 95
    • 25
    • 18
    • 15
    • 6
    • 4
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser CD59 Antikörper ist konjugiert mit APC
    Applikation
    • 134
    • 82
    • 58
    • 52
    • 46
    • 32
    • 29
    • 18
    • 18
    • 18
    • 16
    • 14
    • 14
    • 13
    • 8
    • 3
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    Flow Cytometry (FACS), Functional Studies (Func), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunoprecipitation (IP)
    Spezifität
    The antibody MEM-43 reacts with well defined epitope (W40, R-53) on CD59 (Protectin), an 18-20 kDa glycosylphosphatidylinositol (GPI)-anchored glycoprotein expressed on all hematopoietic cells, it is widely present on cells in all tissues. This antibody does not compete with MEM-43/5.
    HLDA IV, WS Code NL 705
    HLDA V, WS Code AS S013
    HLDA V, WS Code BP BP345
    HLDA V, WS Code T T-103
    Kreuzreaktivität (Details)
    Human
    Immunogen
    Thymocytes and T lymphocytes
    Klon
    MEM-43
    Isotyp
    IgG2a
  • Applikationshinweise
    The reagent is designed for Flow Cytometry analysis of human blood cells using 10 μ,l reagent / 100 μ,l of whole blood or 106 cells in a suspension.The content of a vial (1 ml) is sufficient for 100 tests.
    Kommentare

    The purified antibody is conjugated with cross-linked Allophycocyanin (APC) under optimum conditions. The conjugate is purified by size-exclusion chromatography and adjusted for direct use. No reconstitution is necessary.

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Rekonstitution
    No reconstitution is necessary.
    Buffer
    The reagent is provided in stabilizing phosphate buffered saline (PBS) solution containing 15 mM sodium azide.
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handhabung
    Do not freeze.
    Avoid prolonged exposure to light.
    Lagerung
    4 °C
    Informationen zur Lagerung
    Store in the dark at 2-8°C. Do not freeze. Avoid prolonged exposure to light. Do not use after expiration date stamped on vial label.
  • Omidvar, Wang, Brennan, Longhi, Smith, Morgan: "Expression of glycosylphosphatidylinositol-anchored CD59 on target cells enhances human NK cell-mediated cytotoxicity." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 176, Issue 5, pp. 2915-23, (2006) (PubMed).

    Stefanová, Horejsí, Ansotegui, Knapp, Stockinger: "GPI-anchored cell-surface molecules complexed to protein tyrosine kinases." in: Science (New York, N.Y.), Vol. 254, Issue 5034, pp. 1016-9, (1991) (PubMed).

    Forsberg, Bazil, Stefanová, Schröder: "Gene for human CD59 (likely Ly-6 homologue) is located on the short arm of chromosome 11." in: Immunogenetics, Vol. 30, Issue 3, pp. 188-93, (1989) (PubMed).

  • Target
    CD59
    Andere Bezeichnung
    CD59 (CD59 Produkte)
    Synonyme
    16.3A5, 1F5, EJ16, EJ30, EL32, G344, HRF-20, HRF20, MAC-IP, MACIF, MEM43, MIC11, MIN1, MIN2, MIN3, MIRL, MSK21, p18-20, Cd59a, Cd59b, MACIP, CD59 molecule (CD59 blood group), CD59 molecule, CD59, Cd59
    Hintergrund
    CD59 (Protectin) is a small (18-20 kDa) GPI-anchored ubiquitously expressed inhibitor of the membrane attack complex (MAC). It is thus the key regulator that preserves the autologous cells from terminal effector mechanism of the complement cascade. CD59 associates with C5b-8 complex and thereby counteracts appropriate formation of cytolytic pore within the plasma membrane. CD59 is also an low-affinity ligand of human CD2 and causes T cell costimulation.
    Pathways
    Komplementsystem
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