Serotonin Receptor 4 Antikörper (Cytoplasmic Domain)

Produktnummer ABIN121987

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch Serotonin Receptor 4 in IHC (p). Er zeigt eine Reaktivität gegenüber Human, Ratte und Maus.

Kurzübersicht für Serotonin Receptor 4 Antikörper (Cytoplasmic Domain) (ABIN121987)

Target: Serotonin Receptor 4 (HTR4)

Reaktivität: Human, Ratte, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Serotonin Receptor 4 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Produktdetails anti-Serotonin Receptor 4 Antikörper

Bindungsspezifität: Cytoplasmic Domain

Spezifität: Reacts with 5-HT4 Receptor (family: GPCR, subfamily: Serotonin).

Kreuzreaktivität (Details): Species reactivity (expected):Mouse and Rat.
Species reactivity (tested):Human.

Aufreinigung: Immunoaffinity Chromatography.

Immunogen: Synthetic peptide - KLH conjugated

Anwendungsinformationen

Applikationshinweise: Immunohistochemistry with Formalin Fixed Paraffin Embedded Tissues: 6 μg/mL. Antigen retrieval: Steam slides in 0.01 M sodium citrate buffer, pH 6.0 at 99-100 °C for 20 min. Remove from heat and let stand at room temperature in buffer for 20 min.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. Further Comments: This product was originally produced by MBL International.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: PBS containing 0.09 % Sodium Azide as preservative.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 to -70 °C forlonger. Avoid repeated freezing and thawing.
Shelf life: one year from despatch.

Haltbarkeit: 12 months

Details zu Serotonin Receptor 4

Target: Serotonin Receptor 4 (HTR4)

Andere Bezeichnung: Serotonin Receptor 4 / HTR4

Hintergrund: The 5-HT4 receptor, a member of the Serotonin Receptor subfamily, has been shown to affect the sensory and motor functions of the gut. Some of the most promising emerging therapies in Irritable Bowel Syndrome revolve around targeted pharmacotherapeutic modulation of serotonin receptors (ie, 5-HT3 and 5-HT4 subtypes). At least 9 isoforms (5-HT4A-5-HT4G, and 5-HT4n) have been described, which differ in the length and composition of their intracellular C termini after a common splicing site (L358). A ninth isoform (5-HT4H) results in the insertion of 14 amino acids into the second intracellular loop. 5-HT4 receptor expression has been documented primarily in the brain, and in colon, heart, and vessel. An EST has been isolated from a human cancerous nerve library. Ligand: Serotonin.Synonyms: 5-HT-4, 5-HT4, 5-hydroxytryptamine receptor 4

Gen-ID: 3360

UniProt: Q13639

Pathways: JAK-STAT Signalweg, cAMP Metabolic Process, S100 Proteine