CXCR3 Antikörper (C-Term)

Produktnummer ABIN121951

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch CXCR3 in IHC (p). Es zeigt Reaktivität gegenüber Proben von Human.

Kurzübersicht für CXCR3 Antikörper (C-Term) (ABIN121951)

Target: CXCR3 (Chemokine (C-X-C Motif) Receptor 3 (CXCR3))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CXCR3 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Produktdetails anti-CXCR3 Antikörper

Bindungsspezifität: C-Term

Spezifität: Recognizes Human CXC Chemokine Receptor type 3 (Family: GPCR, Subfamily: Chemokine). BLAST analysis of the peptide immunogen showed no homology with other Human proteins, except SRRM2 (59 %).

Kreuzreaktivität (Details): Species reactivity (tested):Human.

Aufreinigung: Immunoaffinity Chromatography

Immunogen: Synthetic peptide - KLH conjugated.

Anwendungsinformationen

Applikationshinweise: Immunohistochemistry on paraffin embedded sections: 16 μg/mL. Antigen Retrieval: Steam slides in 0.01 M sodium citrate buffer, pH 6.0, at 99-100 °C for 20 min. Remove from heat and let stand at room temperature in buffer for 20 min. Rinse in 1x TBS with Tween (TBST) for 1 min. at room temperature.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. Further Comments: This product was originally produced by MBL International.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: PBS, 0.09 % Sodium Azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 to -70 °C forlonger. Avoid repeated freezing and thawing.
Shelf life: one year from despatch.

Haltbarkeit: 12 months

Details zu CXCR3

Target: CXCR3 (Chemokine (C-X-C Motif) Receptor 3 (CXCR3))

Andere Bezeichnung: CD183 / CXCR3

Hintergrund: CXCR3, a Chemokine Receptor, is highly similar to the interleukine 8B receptor and has been shown to mediate recruitment of T cells to sites of inflammation and retention of T-cells in the inflamed CNS. CXCR3 has been suggested to be the principal inflammatory chemokine receptor involved in intrathecal accumulation of T-cells in multiple sclerosis and diabetes. It is expressed on malignant B cells in chronic lymphoproliferative disorders (Jones et al., 2000). Ligand: Interferon gamma-inducible protein 9, Interferon gamma-inducible protein 10 and Interferon gamma inducible CXC chemokines I-TAC, IP10 and Mig. An alternatively spliced isoform, CXCR3B, has recently been identified (Lasagni et al. 2003). CXCR3 expression has been documented in the brain, lymphoid and other peripheral tissues, and in diseasess including atheroslerosis, Alzheimer's, multiple sclerosis, rheumatoid arthritis, lymphomas, asthma, neoplasms, leukemia, and inflammatory conditions of various organs.Synonyms: CXC-R3, CXCR-3, G protein-coupled receptor 9, GPR9, IP-10 receptor, IP10 receptor, Interferon-inducible protein 10 receptor

Gen-ID: 2833

UniProt: P49682