TSC1 Antikörper

Produktnummer ABIN121908

Produktdetails anti-TSC1 Antikörper

Target: TSC1 (Tuberous Sclerosis 1 (TSC1))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TSC1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF)

Spezifität: This antibody recognises an epitope within the internal region of the 130 kDa tumour suppressor protein, Tumour sclerosis complex 1 (TSC1).

Aufreinigung: Affinity chromatography

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: Phosphate buffered saline, 0.02 % Sodium Azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Details zu TSC1

Target: TSC1 (Tuberous Sclerosis 1 (TSC1))

Andere Bezeichnung: TSC1 / Hamartin (TSC1 Produkte)

Hintergrund: Mutation within the TSC1 gene is responsible for Tuberous sclerosis (TSC), an autosomal dominant genetic disorder associated with the development of benign tumors (hamartomas), a condition also induced by mutation of the Tumour sclerosis complex 2 (TSC2) gene. Many proteins have been shown to play a role in the regulation of the serine/threonine kinase known as target of rapamycin (TOR), a central component in a complex signaling pathway which controls cell proliferation and cell cycle progression. Negative regulation of TOR activity occurs following the over-expression of the TSC1 and TSC2 gene products, hamartin and tuberin. These act by suppressing the phosphorylation of eukaryotic translation initiation factor 4E binding protein 1 (4EBP1) and ribosomal protein S6 kinase (S6K), downstream targets of TOR involved in mRNA translation. Furthermore the TOR activator protein Rheb has been identified as a target of TSC1-TSC2 complexes.Synonyms: KIAA0243, TSC, Tuberous sclerosis 1 protein

Gen-ID: 7248

UniProt: Q92574

Pathways: RTK Signalweg, AMPK Signaling, Regulation of Cell Size, Tube Formation