CD59 Antikörper (PE)

Produktnummer ABIN119474

Der Ratte Monoklonal Anti-CD59-Antikörper wurde für FACS validiert. Er ist geeignet, CD59 in Proben von Human zu detektieren.

Kurzübersicht für CD59 Antikörper (PE) (ABIN119474)

Target: CD59

Reaktivität: Human

Wirt: Ratte

Klonalität: Monoklonal

Konjugat: Dieser CD59 Antikörper ist konjugiert mit PE

Applikation: Flow Cytometry (FACS)

Klon: YTH53-1

Produktdetails anti-CD59 Antikörper (PE)

Spezifität: Clustered at the fourth leucocyte typing workshop to designation CD59. YTH53.1 reacts with CD59 transfectants. It enhances antibody-mediated lysis by homologous complement and reacts with GPI-linked antigen of 18-20 kDa size which is broadly expressed on human leucocytes and erythrocytes. Putative ligand for CD2.

Aufreinigung: Ion exchange chromatography

Immunogen: Human Peripheral Blood T cells. Spleen cells from immunised DA rat fused with the Y3/Ag1.2.3 meloma cell line.

Isotyp: IgG2b

Anwendungsinformationen

Applikationshinweise: Flow cytometry: We do not recommend using this antibody in lysed whole blood techniques due to inhibition of staining caused by CD59 expression on erythrocytes.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Rekonstitution: Restore with 1 mL distilled water

Buffer: PBS, pH 7.2 containing 0.09 % Sodium Azide and 1 % Bovine Serum Albumin

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: -20 °C

Informationen zur Lagerung: Aliquot and store at -20 °C.

Details zu CD59

Target: CD59

Andere Bezeichnung: CD59

Hintergrund: CD59, an LY6 like protein expressed in human lymphoid cells, regulates the action of the complement membrane attack complex on homologous cells. It is a potent inhibitor of the complement membrane attack complex action. It acts by binding to the C8 and/or C9 complements of the membrane attack complex, thereby preventing incorporation of the multiple copies of C9 required for complete formation of the osmolytic pore. This inhibitor appears to be species-specific. CD59 is also involved in signal transduction for T-cell activation complexed to a protein tyrosine kinase.Synonyms: 20 kDa homologous restriction factor, HRF-20, HRF20, MAC-IP, MAC-inhibitory protein, MACIF, MEM43 antigen, MIC11, MIN1, MIN2, MIN3, MIRL, MSK21, Membrane attack complex inhibition factor, Membrane inhibitor of reactive lysis, Protectin

Gen-ID: 966

NCBI Accession: NP_000602

UniProt: P13987

Pathways: Komplementsystem