CDK6 Antikörper

Produktnummer ABIN119189

Der Maus Monoklonal anti-CDK6 Antikörper wird verwendet zum Nachweis von CDK6 in Proben von Human. Er wurde validiert für WB, IP und IHC (fro).

Kurzübersicht für CDK6 Antikörper (ABIN119189)

Target: CDK6 (Cyclin-Dependent Kinase 6 (CDK6))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser CDK6 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunoprecipitation (IP), Immunohistochemistry (Frozen Sections) (IHC (fro))

Klon: DCS-83-1

Produktdetails anti-CDK6 Antikörper

Spezifität: This antibody recognises Cyclin Dependent Kinase 6 (Cdk6), a 40 kDa protein which plays an important role in the progression of G1 to S.

Kreuzreaktivität (Details): Species reactivity (tested):Human.

Aufreinigung: Purified

Immunogen: Recombinant CDK6 protein.

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: Western Blot. Immunoprecipitation. Immunohistochemistry on frozen sections. Recommended positive control tissue: U-2-OS sarcoma cell line.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: PBS, 0.08 % Sodium Azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Details zu CDK6

Target: CDK6 (Cyclin-Dependent Kinase 6 (CDK6))

Andere Bezeichnung: CDK6

Hintergrund: Cdk6 is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This kinase is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression and G1/S transition. The activity of Cdk6 first appears in mid-G1 phase, and is controlled by regulatory subunits including D-type cyclins and members of INK4 family of CDK inhibitors. This kinase, as well as CDK4, has been shown to phosphorylate, and thus regulate the activity of, tumor suppressor protein Rb.Synonyms: Cell division protein kinase 6, PLSTIRE, Serine/threonine-protein kinase PLSTIRE

Gen-ID: 1021

NCBI Accession: NP_001138778

UniProt: Q00534

Pathways: Zellzyklus, Mitotic G1-G1/S Phases