CD59 Antikörper

Produktnummer ABIN118752

Dieses Anti-CD59-Antikörper ist ein Maus Monoklonal-Antikörper zur Detektion von CD59 in FACS, IP und IHC (p). Geeignet für Human.

Kurzübersicht für CD59 Antikörper (ABIN118752)

Target: CD59

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser CD59 Antikörper ist unkonjugiert

Applikation: Flow Cytometry (FACS), Immunoprecipitation (IP), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Klon: MEM-43

Produktdetails anti-CD59 Antikörper

Spezifität: The antibody reacts with well defined epitope (W40, R-53) on CD59 (Protectin), an 18-20 kDa glycosylphosphatidylinositol (GPI)-anchored glycoprotein expressed on all hematopoietic cells, it is widely present on cells in all tissues.

Kreuzreaktivität (Details): Species reactivity (tested):Human

Aufreinigung: Affinity Chromatography on Protein A

Immunogen: Thymocytes and T lymphocytes

Isotyp: IgG2a

Anwendungsinformationen

Applikationshinweise: Immunoprecipitation. Flow Cytometry. Immunohistochemistry (paraffin sections) Recommended dilution: 10 m g/mL, Positive tissue: placenta
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: Phosphate buffered saline (PBS) with 15 mM Sodium Azide as preservative, approx. pH 7.4

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Details zu CD59

Target: CD59

Andere Bezeichnung: CD59

Hintergrund: CD59 (Protectin) is a small (18-20 kDa) GPI-anchored ubiquitously expressed inhibitor of the membrane attack complex (MAC). It is thus the key regulator that preserves the autologous cells from terminal effector mechanism of the complement cascade. CD59 associates with C5b-8 complex and thereby counteracts appropriate formation of cytolytic pore within the plasma membrane. CD59 is also an low-affinity ligand of human CD2 and causes T cell costimulation.Synonyms: 20 kDa homologous restriction factor, HRF-20, HRF20, MAC-IP, MAC-inhibitory protein, MACIF, MEM43 antigen, MIC11, MIN1, MIN2, MIN3, MIRL, MSK21, Membrane attack complex inhibition factor, Membrane inhibitor of reactive lysis, Protectin

Gen-ID: 966

NCBI Accession: NP_000602

UniProt: P13987

Pathways: Komplementsystem