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ITGA2 Antikörper

Dieses Maus Monoklonal-Antikörper erkennt spezifisch ITGA2 in FACS, WB, IP, IHC (p), IHC (fro) und EIA. Er zeigt eine Reaktivität gegenüber Human und Affe.
Produktnummer ABIN118720

Kurzübersicht für ITGA2 Antikörper (ABIN118720)

Target

Alle ITGA2 Antikörper anzeigen
ITGA2 (Integrin alpha 2 (ITGA2))

Reaktivität

  • 127
  • 74
  • 19
  • 9
  • 9
  • 9
  • 8
  • 6
  • 3
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
Human, Affe

Wirt

  • 80
  • 53
  • 30
  • 9
  • 8
Maus

Klonalität

  • 111
  • 72
Monoklonal

Konjugat

  • 84
  • 27
  • 19
  • 16
  • 8
  • 5
  • 4
  • 3
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser ITGA2 Antikörper ist unkonjugiert

Applikation

  • 91
  • 78
  • 57
  • 38
  • 35
  • 27
  • 21
  • 13
  • 12
  • 6
  • 6
  • 5
  • 3
  • 2
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
Flow Cytometry (FACS), Western Blotting (WB), Immunoprecipitation (IP), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Enzyme Immunoassay (EIA)

Klon

16B4
  • Spezifität

    This antibody is identified as capable of immunoprecipitating a non-reducible alpha subunit from I125 surface labelled cell line extract. It is confirmed as specific to the alpha 2 subunit by relative expression of antigen on various cell lines by FACS, and its recognition of affinity purified alpha 2 beta 1 in dot blots.

    Kreuzreaktivität (Details)

    Species reactivity (tested):Human.

    Aufreinigung

    Affinity Chromatography on Protein G

    Immunogen

    Purified human beta1 preparation from HT1080 fibrosarcoma cell extract. Spleen cells from immunised BALB/c mice were fused with cells of the X63/Ag8.653 mouse myeloma cell line.

    Isotyp

    IgG1
  • Applikationshinweise

    Flow Cytometry: 30 μg/mL, Immunoprecipitation: 25-50 μg/mL. Immunohistochemistry on Frozen Sections: 30-40 μg/mL. ELISA: 10 μg/mL. Western Blot.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Konzentration

    1.0 mg/mL

    Buffer

    PBS, pH 7.4 containing 0.09 % Sodium Azide as preservative.

    Konservierungsmittel

    Sodium azide

    Vorsichtsmaßnahmen

    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Handhabung

    Avoid repeated freezing and thawing.

    Lagerung

    4 °C/-20 °C

    Informationen zur Lagerung

    Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
  • Target

    ITGA2 (Integrin alpha 2 (ITGA2))

    Andere Bezeichnung

    CD49b / ITGA2

    Hintergrund

    CD49b, a member of the integrin family of extracellular matrix and cell adhesion molecules, is the integrin alpha-2 chain. CD49b associates noncovalently with CD29, the integrin beta-1 subunit, to form the heterodimer integrin a2b1 that binds laminin and collagen. It is expressed on B and T lymphocytes, NK cells, monocytes, platelets, fibroblasts and long-term cultured T cells. CD49b/CD29 mediates the Mg++ dependent adhesion of platelets to collagen. It may also be utilized by fibroblasts for the reorganization of the collagen matrix during would healing.Synonyms: CD49 antigen-like family member B, Collagen Receptor, GPIa, ITGA-2, Integrin alpha-2, Platelet membrane glycoprotein Ia, VLA-2 alpha, VLA2

    Gen-ID

    3673

    NCBI Accession

    NP_002194

    UniProt

    P17301

    Pathways

    CXCR4-mediated Signaling Events, Smooth Muscle Cell Migration, Integrin Complex
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