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Integrin alpha 1 Antikörper (FITC)

ITGA1 Reaktivität: Human FACS Wirt: Maus Monoclonal TS2-7 FITC
Produktnummer ABIN118691
  • Target Alle Integrin alpha 1 (ITGA1) Antikörper anzeigen
    Integrin alpha 1 (ITGA1)
    Reaktivität
    • 68
    • 34
    • 21
    • 4
    • 1
    Human
    Wirt
    • 53
    • 17
    • 4
    • 1
    • 1
    Maus
    Klonalität
    • 58
    • 18
    Monoklonal
    Konjugat
    • 35
    • 6
    • 4
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser Integrin alpha 1 Antikörper ist konjugiert mit FITC
    Applikation
    • 51
    • 25
    • 23
    • 15
    • 14
    • 13
    • 13
    • 7
    • 6
    • 6
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Flow Cytometry (FACS)
    Aufreinigung
    Affinity Chromatography on Protein G.
    Klon
    TS2-7
    Isotyp
    IgG1
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  • Applikationshinweise
    Flow cytometry: Neat-1/5, Use 10 μL of the suggested working dilution to label 10^6 cells in 100 μL.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Konzentration
    0.1 mg/mL
    Buffer
    PBS, pH 7.4 containing 0.09 % Sodium Azide as preservative and 1 % BSA as stabilizer.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handhabung
    Avoid repeated freezing and thawing. This product is photosensitive and should be protected from light
    Lagerung
    4 °C/-20 °C
    Informationen zur Lagerung
    Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
  • Target
    Integrin alpha 1 (ITGA1)
    Andere Bezeichnung
    CD49a / ITGA1 (ITGA1 Produkte)
    Synonyme
    CD49A antikoerper, E130012M19Rik antikoerper, Vla1 antikoerper, CD49a antikoerper, VLA1 antikoerper, integrin alpha 1 antikoerper, integrin subunit alpha 1 antikoerper, Itga1 antikoerper, ITGA1 antikoerper
    Hintergrund
    Integrins are important extracellular matrix (ECM) receptor proteins located on cell surfaces. They are hetrodimers composed of an alpha and a beta transmembrane glycoprotein subunit. Around twenty two different integrins (different alpha/ beta subunit combinations) are found in nature. Integrins are generally present in high concentrations at the cell surface, but, unlike most other cell surface receptors, they bind ligands with very low affinity. Due to their weak individual binding, integrins need to cluster and bind in groups in order to effectively bind the ECM. Integrins bind many different ligands including laminin. Each integrin is made up of a large N terminal extracellular domain that binds the ECM ligand and a small C terminal cytoplasmic domain that mediates interaction with the actin cytoskeleton and signaling function. Alpha 1 integrin along with alpha 2, alpha L and alpha M has a unique inserted domain. Integrin alpha 1 is a receptor for laminin and collagen. The alpha1 subunit is also known as CD49a. CD49a associates with CD29 (beta 1 integrin), to form an alpha1 beta1 heterodimer, identified as the rat homologue to VLA1, which is involved in cellular adhesion to laminin and collagen.Synonyms: CD49 antigen-like family member A, ITGA-1, Integrin alpha-1, Laminin and Collagen Receptor, VLA-1, VLA1
    Gen-ID
    3672
    NCBI Accession
    NP_852478
    UniProt
    P56199
    Pathways
    EGFR Signaling Pathway, CXCR4-mediated Signaling Events, Signaling of Hepatocyte Growth Factor Receptor, Integrin Complex
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