WIPF1 Antikörper (pSer488) (PE)

Produktnummer ABIN1177221

Zitiert in 1 Publikation. Der PE-konjugierte Maus Monoklonal anti-WIPF1 Antikörper (Klon K32-824) (ABIN1177221) detektiert spezifisch WIPF1 in ICS. Dieser Antikörper reagiert spezifisch mit Proben aus Human, Maus und Ratte.

Kurzübersicht für WIPF1 Antikörper (pSer488) (PE) (ABIN1177221)

Target: WIPF1 (WAS/WASL Interacting Protein Family, Member 1 (WIPF1))

Reaktivität: Human, Maus, Ratte

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser WIPF1 Antikörper ist konjugiert mit PE

Applikation: Intracellular Staining (ICS)

Klon: K32-824

Produktdetails anti-WIPF1 Antikörper (PE)

Bindungsspezifität: pSer488

Marke: BD Phosflow™

Aufreinigung: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Immunogen: Phosphorylated Human WIP Peptide

Isotyp: IgG1 kappa

Anwendungsinformationen

Probenmenge: 20 μL

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Aqueous buffered solution containing BSA and ≤0.09 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze. The antibody was conjugated with R-PE under optimum conditions, and unconjugated antibody and free PE were removed.

Referenzen für anti-WIPF1 Antikörper (PE) (ABIN1177221)

Aspenström: "The verprolin family of proteins: regulators of cell morphogenesis and endocytosis." in: FEBS letters, Vol. 579, Issue 24, pp. 5253-9, (2005) (PubMed).

Details zu WIPF1

Target: WIPF1 (WAS/WASL Interacting Protein Family, Member 1 (WIPF1))

Andere Bezeichnung: WIP

Hintergrund: Wiskott-Adrich syndrome protein (WASP)-Interacting Protein (WIP) is a member of the verprolin family of proteins that regulate cytoskeletal organization in a wide variety of cellular activities, including endocytosis, cellular adhesion and migration, mast cell degranulation, and lymphocyte activation. The 503-amino acid WIP protein contains binding sites for actin (globular and filamentous) and other proteins that are involved in the regulation of actin polymerization, such as WASP, N-WASP, profilin, cortactin, Hck, and NCK. As its functions imply, WIP is localized in actin-rich cell structures. The K32-824 monoclonal antibody recognizes the phosphorylated serine 488 (pS488) of human WIP. The orthologous phosphorylation sites in mouse and rat WIP are S478 and S472, respectively.

Pathways: RTK Signalweg