BCAR1
Reaktivität: Human
WB, IF
Wirt: Kaninchen
Polyclonal
unconjugated
Probenmenge
20 μL
Beschränkungen
Nur für Forschungszwecke einsetzbar
Format
Liquid
Buffer
Aqueous buffered solution containing BSA and ≤0.09 % sodium azide.
Konservierungsmittel
Sodium azide
Vorsichtsmaßnahmen
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung
4 °C
Informationen zur Lagerung
The antibody was conjugated to Alexa Fluor® 647 under optimum conditions, and unreacted Alexa Fluor® 647 was removed. Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Goldberg, Alexander, Pellicena, Zhang, Tsuda, Miller: "Src phosphorylates Cas on tyrosine 253 to promote migration of transformed cells." in: The Journal of biological chemistry, Vol. 278, Issue 47, pp. 46533-40, (2003) (PubMed).
Hinsby, Olsen, Bennett, Mann: "Signaling initiated by overexpression of the fibroblast growth factor receptor-1 investigated by mass spectrometry." in: Molecular & cellular proteomics : MCP, Vol. 2, Issue 1, pp. 29-36, (2003) (PubMed).
Target
BCAR1
(Breast Cancer Anti-Estrogen Resistance 1 (BCAR1))
CAS antikoerper, CAS1 antikoerper, CASS1 antikoerper, CRKAS antikoerper, P130Cas antikoerper, AI385681 antikoerper, Cas antikoerper, Crkas antikoerper, P130CAS antikoerper, MGC68466 antikoerper, cas antikoerper, p130cas antikoerper, BCAR1 antikoerper, fc17f11 antikoerper, wu:fc17f11 antikoerper, zgc:175192 antikoerper, BCAR1, Cas family scaffolding protein antikoerper, breast cancer anti-estrogen resistance 1 antikoerper, breast cancer anti-estrogen resistance 1 L homeolog antikoerper, breast cancer anti-estrogen resistance protein 1 antikoerper, BCAR1 antikoerper, Bcar1 antikoerper, bcar1.L antikoerper, bcar1 antikoerper, LOC100435586 antikoerper
Hintergrund
P47v-crk (v-Crk) is the product of a transforming gene, v-crk, that was isolated from avian sarcoma viruses. The v-Crk protein is a fusion product of viral Gag protein and a part of cellular Crk that includes SH2 and SH3 domains. v-Crk-induced transformation increases tyrosine phosphorylation of several cellular proteins, including p130Cas (CRK-associated substrate). The p130Cas is tightly associated with v-Crk via the SH2 domain of v-Crk. Tyrosine phosphorylation of p130Cas occurs in conjunction with cellular transformation in cells that express v-Src or v-Crk. This phosphorylation leads to a change in p130Cas localization from the cytoplasm to the cell membrane and, possibly, to the nucleus. Since p130Cas also associates with v-Src, it may be a v-Src substrate. Several phosphorylation sites have been described in p130Cas upon Fibroblast Growth Factor stimulation, and phosphorylated tyrosine (Y249) might function as a binding site for the Crk-adaptor molecule. The J169-757.12.2 monoclonal antibody recognizes the phosphorylated Y249 of human p130Cas. The orthologous phosphorylation sites in mouse and rat p130Cas are Y253 and Y347, respectively.