B-Cell Linker Antikörper (pTyr84) (Alexa Fluor 647)
(2 Referenzen)-
- Target Alle B-Cell Linker (BLNK) Antikörper anzeigen
- B-Cell Linker (BLNK)
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Bindungsspezifität
- pTyr84
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Reaktivität
- Human, Maus
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Wirt
- Maus
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Klonalität
- Monoklonal
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Konjugat
- Dieser B-Cell Linker Antikörper ist konjugiert mit Alexa Fluor 647
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Applikation
- Intracellular Staining (ICS)
- Marke
- BD Phosflow™
- Aufreinigung
- The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
- Immunogen
- Phosphorylated Human BLNK Peptide
- Klon
- J117-1278
- Isotyp
- IgG2b kappa
- Top Product
- Discover our top product BLNK Primärantikörper
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anti-B-Cell Linker (BLNK) antibody
BLNK Reaktivität: Human WB, ELISA, IHC, FACS, ICC Wirt: Maus Monoclonal 5G9 unconjugated
anti-B-Cell Linker (BLNK) (AA 65-314) antibodyBLNK Reaktivität: Human WB, IHC, ICC, IP Wirt: Kaninchen Polyclonal unconjugated
anti-B-Cell Linker (BLNK) (AA 301-400) antibodyBLNK Reaktivität: Human WB, ELISA, PLA Wirt: Maus Monoclonal 1D7 unconjugated
anti-B-Cell Linker (BLNK) (C-Term) antibodyVerified BLNK Reaktivität: Human WB, ELISA, FACS, IF Wirt: Ziege Polyclonal unconjugated
anti-B-Cell Linker (BLNK) (AA 41-337) antibodyBLNK Reaktivität: Human WB, ELISA, IHC, IF Wirt: Kaninchen Polyclonal unconjugated
anti-B-Cell Linker (BLNK) (pTyr96) antibodyBLNK Reaktivität: Human WB, ELISA, IF (p), IHC (p), IF (cc), IHC (fro) Wirt: Kaninchen Polyclonal unconjugated
anti-B-Cell Linker (BLNK) (AA 150-178) antibodyBLNK Reaktivität: Human WB, FACS, IHC (p) Wirt: Kaninchen Polyclonal RB18883 unconjugated
anti-B-Cell Linker (BLNK) (pTyr96) antibodyBLNK Reaktivität: Human, Maus WB, ELISA, IHC, ICC, IF Wirt: Kaninchen Polyclonal unconjugated
anti-B-Cell Linker (BLNK) (N-Term) antibodyBLNK Reaktivität: Human, Maus WB, ELISA, IHC, ICC, IF Wirt: Kaninchen Polyclonal unconjugated
anti-B-Cell Linker (BLNK) (pTyr84) antibodyBLNK Reaktivität: Human WB, ELISA, IHC Wirt: Kaninchen Polyclonal unconjugated
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- Probenmenge
- 20 μL
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Buffer
- Aqueous buffered solution containing BSA and ≤0.09 % sodium azide.
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- 4 °C
- Informationen zur Lagerung
- Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze. The antibody was conjugated to Alexa Fluor® 647 under optimum conditions, and unreacted Alexa Fluor® 647 was removed.
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: "Phospho-proteomic analysis of mantle cell lymphoma cells suggests a pro-survival role of B-cell receptor signaling." in: Cellular oncology (Dordrecht), Vol. 34, Issue 2, pp. 141-53, (2011) (PubMed).
: "Impaired B-cell development at the pre-BII-cell stage in galectin-1-deficient mice due to inefficient pre-BII/stromal cell interactions." in: Blood, Vol. 113, Issue 23, pp. 5878-86, (2009) (PubMed).
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: "Phospho-proteomic analysis of mantle cell lymphoma cells suggests a pro-survival role of B-cell receptor signaling." in: Cellular oncology (Dordrecht), Vol. 34, Issue 2, pp. 141-53, (2011) (PubMed).
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- Target
- B-Cell Linker (BLNK)
- Andere Bezeichnung
- BLNK (BLNK Produkte)
- Hintergrund
- B cell activation is initiated by crosslinking the B cell receptor, which leads to activation of non-receptor protein tyrosine kinases (PTK), including Btk, Syk, and three Src kinases, Fyn, Lyn, and Blk. Activated PTKs then phosphorylate multiple cellular proteins involved in B lymphocyte signaling. Syk is responsible for the tyrosine phosphorylation of B cell linker protein (BLNK), a member of the SLP-76 family of adapter proteins. Phosphorylation of human BLNK at tyrosines 84, 178, and 189 (Y84, Y178, and Y189) creates docking sites for PLCg2, leading to the activation of downstream signaling pathways. The J117-1278 monoclonal antibody recognizes the phosphorylated Y84 of BLNK.
- Pathways
- BCR Signaling
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