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VCAM1 Antikörper

VCAM1 Reaktivität: Maus FACS, IP, IF, IHC (fro), BR Wirt: Ratte Monoclonal 429 unconjugated
Produktnummer ABIN1176996
  • Target Alle VCAM1 Antikörper anzeigen
    VCAM1 (Vascular Cell Adhesion Molecule 1 (VCAM1))
    Reaktivität
    • 138
    • 106
    • 57
    • 25
    • 15
    • 8
    • 8
    • 4
    • 3
    • 1
    Maus
    Wirt
    • 96
    • 76
    • 43
    • 5
    • 1
    • 1
    Ratte
    Klonalität
    • 129
    • 91
    • 1
    Monoklonal
    Konjugat
    • 97
    • 27
    • 25
    • 14
    • 5
    • 5
    • 4
    • 4
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser VCAM1 Antikörper ist unkonjugiert
    Applikation
    • 115
    • 108
    • 55
    • 43
    • 39
    • 34
    • 27
    • 26
    • 24
    • 16
    • 16
    • 13
    • 8
    • 7
    • 6
    • 5
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Flow Cytometry (FACS), Immunoprecipitation (IP), Immunofluorescence (IF), Immunohistochemistry (Frozen Sections) (IHC (fro)), Blocking Reagent (BR)
    Marke
    BD Pharmingen™
    Aufreinigung
    The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
    Sterilität
    0.2 μm filtered
    Endotoxin-Niveau
    Endotoxin level is ≤ 0.01 EU/μg (≤ 0.001 ng/μg) of protein as determined by the LAL assay.
    Immunogen
    Mouse preadipose cell line PA6
    Klon
    429
    Isotyp
    IgG2a kappa
    Top Product
    Discover our top product VCAM1 Primärantikörper
  • Applikationshinweise
    For IHC, we recommend the use of purified 429 mAb in our special formulation for immunohistochemistry, Cat. No. 550547.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Konzentration
    1.0 mg/mL
    Buffer
    No azide/low endotoxin: Aqueous buffered solution containing no preservative, 0.2μm sterile filtered.
    Konservierungsmittel
    Azide free
    Lagerung
    4 °C
    Informationen zur Lagerung
    Store undiluted at 4°C. This preparation contains no preservatives, thus it should be handled under aseptic conditions.
  • Koni, Joshi, Temann, Olson, Burkly, Flavell: "Conditional vascular cell adhesion molecule 1 deletion in mice: impaired lymphocyte migration to bone marrow." in: The Journal of experimental medicine, Vol. 193, Issue 6, pp. 741-54, (2001) (PubMed).

    Buck, Edelman, Buck, Kennedy, Baldwin: "Expression patterns of adhesion receptors in the developing mouse lung: functional implications." in: Cell adhesion and communication, Vol. 4, Issue 2, pp. 69-87, (1997) (PubMed).

    Kinashi, Springer: "Adhesion molecules in hematopoietic cells." in: Blood cells, Vol. 20, Issue 1, pp. 25-44, (1995) (PubMed).

    Kinashi, St Pierre, Springer: "Expression of glycophosphatidylinositol-anchored and -non-anchored isoforms of vascular cell adhesion molecule 1 in murine stromal and endothelial cells." in: Journal of leukocyte biology, Vol. 57, Issue 1, pp. 168-73, (1995) (PubMed).

    Baron, Reich, Visintin, Janeway: "The pathogenesis of adoptive murine autoimmune diabetes requires an interaction between alpha 4-integrins and vascular cell adhesion molecule-1." in: The Journal of clinical investigation, Vol. 93, Issue 4, pp. 1700-8, (1994) (PubMed).

    Bevilacqua: "Endothelial-leukocyte adhesion molecules." in: Annual review of immunology, Vol. 11, Issue 4, pp. 767-804, (1993) (PubMed).

  • Target
    VCAM1 (Vascular Cell Adhesion Molecule 1 (VCAM1))
    Andere Bezeichnung
    CD106 (VCAM1 Produkte)
    Synonyme
    CD106 antikoerper, INCAM-100 antikoerper, Vcam-1 antikoerper, VCAM1B antikoerper, fi76d06 antikoerper, wu:fi76d06 antikoerper, zgc:158875 antikoerper, VCAM1 antikoerper, vascular cell adhesion molecule 1 antikoerper, vascular cell adhesion molecule 1b antikoerper, VCAM1 antikoerper, Vcam1 antikoerper, vcam1b antikoerper, VCAM-1 antikoerper
    Hintergrund
    The 429 antibody reacts with both the long (~110 kDa) transmembrane-spanning form and the truncated (~47 kDa) GPI-linked form of vascular cell adhesion molecule-1 (VCAM-1, CD106). CD106 is constitutively expressed on bone marrow stromal cells, myeloid cells, and splenic dendritic cells. Its expression on endothelial cells is upregulated by inflammatory cytokines and in certain pathologic conditions. CD106 expression has also been detected on apoptotic thymocytes, splenocytes, and lymphoid cell lines. VCAM-1 is a counter-receptor for VLA-4 (alpha4beta1 integrin) and LPAM-1 (alpha4beta7 integrin), and the 429 antibody partially blocks VCAM-1-mediated binding functions. Source of the immunogen was mouse preadipose cell line PA6.
    Synonyms: VCAM-1
    Pathways
    Carbohydrate Homeostasis
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