VCAM1 Antikörper (Vascular Cell Adhesion Molecule 1)

Details for Product anti-VCAM1 Antibody No. ABIN1176996
Antigen
  • CD106
  • INCAM-100
  • Vcam-1
  • VCAM1B
  • fi76d06
  • wu:fi76d06
  • zgc:158875
  • VCAM1
  • vascular cell adhesion molecule 1
  • vascular cell adhesion molecule 1b
  • VCAM1
  • Vcam1
  • vcam1b
  • VCAM-1
Reaktivität
Maus
455
188
96
33
11
9
8
8
3
Wirt
Ratte
332
179
93
16
13
8
Klonalität (Klon)
Monoklonal ()
Konjugat
Dieser VCAM1 Antikörper ist unkonjugiert
67
53
52
15
12
9
9
6
5
5
5
5
4
3
3
3
3
3
3
3
3
3
3
3
3
3
2
2
2
2
2
2
2
2
2
2
2
1
Applikation
Blocking Reagent (BR), Immunohistochemistry (Frozen Sections) (IHC (fro)), Flow Cytometry (FACS), Immunofluorescence (IF), Immunoprecipitation (IP)
341
236
205
156
138
103
59
46
42
26
26
24
17
13
10
5
3
3
2
1
1
Optionen
Marke BD Pharmingen™
Immunogen Mouse preadipose cell line PA6
Klon 429
Isotyp IgG2a, kappa
Reinigung The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
Sterilität 0.2 μm filtered
Endotoxin-Niveau Endotoxin level is ≤ 0.01 EU/μg (≤ 0.001 ng/μg) of protein as determined by the LAL assay.
Plasmids, Primers & others Plasmide, Primers & weitere VCAM1 products on genomics-online (e.g. as negative or positive controls)
Antigen
Andere Bezeichnung CD106 (VCAM1 Antibody Abstract)
Hintergrund The 429 antibody reacts with both the long (~110 kDa) transmembrane-spanning form and the truncated (~47 kDa) GPI-linked form of vascular cell adhesion molecule-1 (VCAM-1, CD106). CD106 is constitutively expressed on bone marrow stromal cells, myeloid cells, and splenic dendritic cells. Its expression on endothelial cells is upregulated by inflammatory cytokines and in certain pathologic conditions. CD106 expression has also been detected on apoptotic thymocytes, splenocytes, and lymphoid cell lines. VCAM-1 is a counter-receptor for VLA-4 (alpha4beta1 integrin) and LPAM-1 (alpha4beta7 integrin), and the 429 antibody partially blocks VCAM-1-mediated binding functions. Source of the immunogen was mouse preadipose cell line PA6.
Synonyms: VCAM-1
Pathways Carbohydrate Homeostasis
Applikations-hinweise For IHC, we recommend the use of purified 429 mAb in our special formulation for immunohistochemistry, Cat. No. 550547.
Beschränkungen Nur für Forschungszwecke einsetzbar
Konzentration 1.0 mg/mL
Buffer No azide/low endotoxin: Aqueous buffered solution containing no preservative, 0.2μm sterile filtered.
Konservierungs-mittel Azide free
Lagerung 4 °C
Informationen zur Lagerung Store undiluted at 4°C. This preparation contains no preservatives, thus it should be handled under aseptic conditions.
Produkt verwendet in: Koni, Joshi, Temann, Olson, Burkly, Flavell: "Conditional vascular cell adhesion molecule 1 deletion in mice: impaired lymphocyte migration to bone marrow." in: The Journal of experimental medicine, Vol. 193, Issue 6, pp. 741-54, 2001 (PubMed).

Buck, Edelman, Buck, Kennedy, Baldwin: "Expression patterns of adhesion receptors in the developing mouse lung: functional implications." in: Cell adhesion and communication, Vol. 4, Issue 2, pp. 69-87, 1997 (PubMed).

Kinashi, Springer: "Adhesion molecules in hematopoietic cells." in: Blood cells, Vol. 20, Issue 1, pp. 25-44, 1995 (PubMed).

Kinashi, St Pierre, Springer: "Expression of glycophosphatidylinositol-anchored and -non-anchored isoforms of vascular cell adhesion molecule 1 in murine stromal and endothelial cells." in: Journal of leukocyte biology, Vol. 57, Issue 1, pp. 168-73, 1995 (PubMed).

Baron, Reich, Visintin, Janeway: "The pathogenesis of adoptive murine autoimmune diabetes requires an interaction between alpha 4-integrins and vascular cell adhesion molecule-1." in: The Journal of clinical investigation, Vol. 93, Issue 4, pp. 1700-8, 1994 (PubMed).

Bevilacqua: "Endothelial-leukocyte adhesion molecules." in: Annual review of immunology, Vol. 11, Issue 4, pp. 767-804, 1993 (PubMed).

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