TWEAK Antikörper

Produktnummer ABIN1176948

Produktdetails anti-TWEAK Antikörper

Target: TWEAK (TNFSF12) (Tumor Necrosis Factor (Ligand) Superfamily, Member 12 (TNFSF12))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser TWEAK Antikörper ist unkonjugiert

Applikation: Flow Cytometry (FACS)

Marke: BD Pharmingen™

Aufreinigung: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Sterilität: 0.2 μm filtered

Endotoxin-Niveau: Endotoxin level is ≤ 0.01 EU/μg (≤ 0.001 ng/μg) of protein as determined by the LAL assay.

Immunogen: Human Tweak Transfected Cell Line

Klon: CARL

Isotyp: IgG3 kappa

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1.0 mg/mL

Buffer: No azide/low endotoxin: Aqueous buffered solution containing no preservative, 0.2μm sterile filtered.

Konservierungsmittel: Azide free

Lagerung: 4 °C

Informationen zur Lagerung: Store undiluted at 4°C. This preparation contains no preservatives, thus it should be handled under aseptic conditions.

Referenzen für anti-TWEAK Antikörper (ABIN1176948)

Llinàs, Lázaro, de Salort, Matesanz-Isabel, Sintes, Engel: "Expression profiles of novel cell surface molecules on B-cell subsets and plasma cells as analyzed by flow cytometry." in: Immunology letters, Vol. 134, Issue 2, pp. 113-21, (2010) (PubMed).

Xu, Okamoto, Ichikawa, Ando, Tasaka, Masuyama, Ogawa, Yagita, Okumura, Nakao: "TWEAK/Fn14 interaction stimulates human bronchial epithelial cells to produce IL-8 and GM-CSF." in: Biochemical and biophysical research communications, Vol. 318, Issue 2, pp. 422-7, (2004) (PubMed).

Nakayama, Kayagaki, Yamaguchi, Okumura, Yagita: "Involvement of TWEAK in interferon gamma-stimulated monocyte cytotoxicity." in: The Journal of experimental medicine, Vol. 192, Issue 9, pp. 1373-80, (2000) (PubMed).

Lynch, Wang, Lund, Chen, Leal, Wiley: "TWEAK induces angiogenesis and proliferation of endothelial cells." in: The Journal of biological chemistry, Vol. 274, Issue 13, pp. 8455-9, (1999) (PubMed).

Chicheportiche, Bourdon, Xu, Hsu, Scott, Hession, Garcia, Browning: "TWEAK, a new secreted ligand in the tumor necrosis factor family that weakly induces apoptosis." in: The Journal of biological chemistry, Vol. 272, Issue 51, pp. 32401-10, (1998) (PubMed).

Details zu TWEAK

Target: TWEAK (TNFSF12) (Tumor Necrosis Factor (Ligand) Superfamily, Member 12 (TNFSF12))

Andere Bezeichnung: TWEAK (TNFSF12 Produkte)

Synonyme: APO3L antikoerper, DR3LG antikoerper, TWEAK antikoerper, Apo3l antikoerper, Dr3l antikoerper, Dr3lg antikoerper, Tweak antikoerper, TNF superfamily member 12 antikoerper, tumor necrosis factor (ligand) superfamily, member 12 antikoerper, TNFSF12 antikoerper, Tnfsf12 antikoerper

Hintergrund: The CARL-1 monoclonal antibody specifically binds to TWEAK, also known as TNF-related WEAK inducer of apoptosis. The TWEAK cytokine belongs to the tumor necrosis factor (TNF) ligand family and is encoded by the TNFSF12 (Tumor necrosis factor ligand superfamily member 12) gene. TWEAK is present as a type II transmembrane protein form and a smaller, biologically-active secreted isoform. TWEAK is expressed on most tissues and non-lymphoid tumor cell lines but has weak or no expression on hematopoietic lineage cell lines. TWEAK is not detectable on resting peripheral blood mononuclear cells. However, its expression is upregulated on peripheral blood monocytes in response to IFN-gamma stimulation. TWEAK can act through the TWEAK Receptor (aka, TWEAK-R, TNFRSF12A, Fn14, and CD266) to induce a variety of target cellular responses including NF-kB activation, proliferation, apoptosis, IL-8 and GM-CSF production. Clone CARL-2, a different monoclonal antibody, also binds to TWEAK although it binds to a different TWEAK epitope.
Synonyms: TNFSF12, APO3 ligand, APO3L, DR3LG, TNF-related WEAK inducer of apoptosis

Pathways: Apoptose