IFIH1 Antikörper (AA 78-555)
Kurzübersicht für IFIH1 Antikörper (AA 78-555) (ABIN1169453)
Target
Alle IFIH1 Antikörper anzeigenReaktivität
Wirt
Klonalität
Konjugat
Applikation
Klon
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Bindungsspezifität
- AA 78-555
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Spezifität
- Recognizes human MDA5.
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Kreuzreaktivität
- Human
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Aufreinigung
- Purified from concentrated hybridoma tissue culture supernatant.
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Reinheit
- >95 % (SDS-PAGE)
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Immunogen
- Recombinant human MDA5 (aa 78-555).
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Isotyp
- IgG1
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Applikationshinweise
- Optimal working dilution should be determined by the investigator.
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Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Format
- Liquid
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Konzentration
- Lot specific
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Buffer
- In PBS containing 10 % glycerol and 0.02 % sodium azide.
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Konservierungsmittel
- Sodium azide
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Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Lagerung
- 4 °C,-20 °C
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Informationen zur Lagerung
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Short Term Storage: +4°C
Long Term Storage: -20°C
Stable for at least 1 year after receipt when stored at -20°C. -
Haltbarkeit
- 12 months
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- IFIH1 (Interferon Induced with Helicase C Domain 1 (IFIH1))
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Andere Bezeichnung
- MDA5
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Hintergrund
- RIG-I and MDA5 are highly conserved helicases involved in the innate immune response to virus. RIG-I is a member of the DEAD-box RNA helicases and is activated by cytoplasmic dsRNA and 5'-ppp RNA produced during the viral replication. The protein is characterized by a N-terminal region with two caspase recruitment domains (CARD) and a C-terminal region harboring potential ATP-dependent RNA helicase activity. RIG-1 recruits the CARD adaptor inducing IFN-beta (Cardif) in a CARD-CARD-dependent manner resulting in NF-kappaB and IRF3 activation.
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UniProt
- Q9BYX4
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Pathways
- Activation of Innate immune Response
Target
-