Granulin Antikörper

Produktnummer ABIN1169391

Dieses Anti-Granulin-Antikörper ist ein Meerschweinchen Polyklonal-Antikörper zur Detektion von Granulin in WB, IHC und ELISA. Geeignet für Human.

Kurzübersicht für Granulin Antikörper (ABIN1169391)

Target: Granulin (GRN)

Reaktivität: Human

Wirt: Meerschweinchen

Klonalität: Polyklonal

Konjugat: Dieser Granulin Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Produktdetails anti-Granulin Antikörper

Spezifität: Recognizes human progranulin. Detects a band of ~90 kDa by Western blot.

Kreuzreaktivität: Human

Kreuzreaktivität (Details): Weakly cross-reacts with mouse progranulin. Cross-reacts with hGRN-C and hGRN-F.

Sterilität: 0.2 μm filtered

Immunogen: Recombinant human progranulin.

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: 0.2μm-filtered solution in PBS, pH 7.4. Contains no preservatives.

Konservierungsmittel: Without preservative

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Short Term Storage: +4°C
Long Term Storage: -20°C
Stable for at least 6 months after receipt when stored at -20°C.

Haltbarkeit: 6 months

Details zu Granulin

Target: Granulin (GRN)

Andere Bezeichnung: Progranulin

Substanzklasse: Viral Protein

Hintergrund: Progranulin (PGRN) is a widely expressed pluripotent growth factor which plays a role in processes such as development, wound repair and inflammation by activating signaling cascades that control cell cycle progression and cell motility. Its function in the central nervous system is of interest, as mutations in the PGRN gene were found in cases of frontotemporal degeneration (FTLD). In addition, PGRN has also been linked to tumorigenesis. Progranulin is a biomarker for FTLD, other types of Alzheimer's Disease (AD) and potentially for MCI (Mild Cognitive Impairment). Additionally, PGRN is described as a new ligand of TNF receptors and a potential therapeutic against inflammatory disease like arthritis.

UniProt: P28799