PIDD Antikörper

Produktnummer ABIN1169269

Dieser Maus Monoklonal Antikörper detektiert spezifisch PIDD in WB. Es zeigt Reaktivität gegenüber Proben von Maus.

Kurzübersicht für PIDD Antikörper (ABIN1169269)

Target: PIDD (P53-Induced Death Domain Protein (PIDD))

Reaktivität: Maus

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser PIDD Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Klon: Lise-1

Produktdetails anti-PIDD Antikörper

Verwendungszweck: anti-PIDD (mouse), mAb (Lise-1)

Spezifität: Recognizes mouse PIDD.

Produktmerkmale: Monoclonal Antibody. Recognizes mouse PIDD. Isotype: Mouse IgG2bkappa. Clone: Lise-1. Applications: WB. Liquid. In PBS containing 10 % glycerol and 0.02 % sodium azide. PIDD promotes apoptosis downstream of the tumor suppressor as component of the DNA damage/stress response pathway that connects p53/TP53 to apoptosis. It associates with NEMO/IKBKG and RIP1 and enhances sumoylation and ubiquitination of NEMO/IKBKG which is important for activation of the transcription factor NF-kappa-B. It associates with caspase-2 and RAIDD, and induces activation of caspase-2 which is an important regulator in the apoptotic pathways.

Aufreinigung: Purified from concentrated hybridoma tissue culture supernatant.

Reinheit: >95 % (SDS-PAGE)

Immunogen: Mouse PIDD (Death Domain).

Isotyp: IgG2b kappa

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: In PBS containing 10 % glycerol and 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: After opening, prepare aliquots and store at -20 °C.Avoid freeze/thaw cycles.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung:

+4°C

-20°C

Stable for at least 1 year after receipt when stored at -20°C.

Haltbarkeit: 12 months

Details zu PIDD

Target: PIDD (P53-Induced Death Domain Protein (PIDD))

Andere Bezeichnung: PIDD

Hintergrund:

Alternate Names/Synonyms: p53-induced Protein with a Death Domain, Leucine-rich Repeat and Death Domain-containing Protein, Lrdd

Product Description: PIDD promotes apoptosis downstream of the tumor suppressor as component of the DNA damage/stress response pathway that connects p53/TP53 to apoptosis. It associates with NEMO/IKBKG and RIP1 and enhances sumoylation and ubiquitination of NEMO/IKBKG which is important for activation of the transcription factor NF-kappa-B. It associates with caspase-2 and RAIDD, and induces activation of caspase-2 which is an important regulator in the apoptotic pathways.

UniProt: Q9ERV7

Pathways: p53 Signalweg, Caspase Kaskade in der Apoptose, Positive Regulation of Endopeptidase Activity