PIDD Antikörper

Produktnummer ABIN1169269

Produktdetails anti-PIDD Antikörper

Target: PIDD (P53-Induced Death Domain Protein (PIDD))

Reaktivität: Maus

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser PIDD Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Spezifität: Recognizes mouse PIDD.

Kreuzreaktivität: Maus

Aufreinigung: Purified from concentrated hybridoma tissue culture supernatant.

Reinheit: >95 % (SDS-PAGE)

Immunogen: Mouse PIDD (Death Domain).

Klon: Lise-1

Isotyp: IgG2b

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: In PBS containing 10 % glycerol and 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Short Term Storage: +4°C
Long Term Storage: -20°C
Stable for at least 1 year after receipt when stored at -20°C.

Haltbarkeit: 12 months

Details zu PIDD

Target: PIDD (P53-Induced Death Domain Protein (PIDD))

Andere Bezeichnung: PIDD (PIDD Produkte)

Hintergrund: PIDD promotes apoptosis downstream of the tumor suppressor as component of the DNA damage/stress response pathway that connects p53/TP53 to apoptosis. It associates with NEMO/IKBKG and RIP1 and enhances sumoylation and ubiquitination of NEMO/IKBKG which is important for activation of the transcription factor NF-kappa-B. It associates with caspase-2 and RAIDD, and induces activation of caspase-2 which is an important regulator in the apoptotic pathways.

UniProt: Q9ERV7

Pathways: p53 Signalweg, Caspase Kaskade in der Apoptose, Positive Regulation of Endopeptidase Activity