Telefon:
+49 (0)241 95 163 153
Fax:
+49 (0)241 95 163 155
E-Mail:
orders@antikoerper-online.de

LAG3 Antikörper

LAG3 Reaktivität: Human, Affe WB, ELISA, IHC, IP, ICC, Func Wirt: Maus Monoclonal 1-10E-04 unconjugated
Produktnummer ABIN1169112
  • Target Alle LAG3 Antikörper anzeigen
    LAG3 (Lymphocyte-Activation Gene 3 (LAG3))
    Reaktivität
    • 87
    • 39
    • 10
    • 5
    • 4
    • 1
    • 1
    • 1
    • 1
    Human, Affe
    Wirt
    • 52
    • 34
    • 12
    • 4
    Maus
    Klonalität
    • 53
    • 46
    • 1
    Monoklonal
    Konjugat
    • 52
    • 7
    • 6
    • 4
    • 4
    • 3
    • 3
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser LAG3 Antikörper ist unkonjugiert
    Applikation
    • 68
    • 35
    • 33
    • 29
    • 24
    • 21
    • 15
    • 13
    • 12
    • 10
    • 10
    • 6
    • 5
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunoprecipitation (IP), Immunocytochemistry (ICC), Functional Studies (Func)
    Spezifität
    Recognizes human and monkey LAG-3.
    Kreuzreaktivität
    Human, Affe
    Aufreinigung
    Purified from concentrated hybridoma tissue culture supernatant.
    Reinheit
    >95 % (SDS-PAGE)
    Endotoxin-Niveau
    <0.001EU/μg purified protein or <1EU/mg purified protein (LAL test, Lonza).
    Immunogen
    Recombinant human LAG-3.
    Klon
    1-10E-04
    Isotyp
    IgG1
    Top Product
    Discover our top product LAG3 Primärantikörper
  • Applikationshinweise
    Optimal working dilution should be determined by the investigator.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    Lot specific
    Buffer
    In PBS containing 0.02 % sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C,-20 °C
    Informationen zur Lagerung
    Short Term Storage: +4°C
    Long Term Storage: -20°C
    Stable for at least 1 year after receipt when stored at -20°C.
    Haltbarkeit
    12 months
  • Ward, Hall, Cairns, Leggat, Urbaniak, Vickers, Barker: "Clonal regulatory T cells specific for a red blood cell autoantigen in human autoimmune hemolytic anemia." in: Blood, Vol. 111, Issue 2, pp. 680-7, (2008) (PubMed).

    Triebel, Hacene, Pichon: "A soluble lymphocyte activation gene-3 (sLAG-3) protein as a prognostic factor in human breast cancer expressing estrogen or progesterone receptors." in: Cancer letters, Vol. 235, Issue 1, pp. 147-53, (2006) (PubMed).

    Huard, Mastrangeli, Prigent, Bruniquel, Donini, El-Tayar, Maigret, Dréano, Triebel: "Characterization of the major histocompatibility complex class II binding site on LAG-3 protein." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 94, Issue 11, pp. 5744-9, (1997) (PubMed).

    Huard, Gaulard, Faure, Hercend, Triebel: "Cellular expression and tissue distribution of the human LAG-3-encoded protein, an MHC class II ligand." in: Immunogenetics, Vol. 39, Issue 3, pp. 213-7, (1994) (PubMed).

  • Target
    LAG3 (Lymphocyte-Activation Gene 3 (LAG3))
    Andere Bezeichnung
    LAG-3 (LAG3 Produkte)
    Synonyme
    CD223 antikoerper, LAG-3 antikoerper, Ly66 antikoerper, lymphocyte activating 3 antikoerper, lymphocyte-activation gene 3 antikoerper, LAG3 antikoerper, Lag3 antikoerper
    Hintergrund
    Lymphocyte activation gene 3 (LAG-3, CD223) plays an important role in negatively regulating T cell proliferation, function and homeostasis. It is required for maximal natural and induced regulatory T cell (Treg) function. LAG-3 is closely related to the T cell co-receptor CD4 and binds to MHC class II molecules but with a significantly higher affinity than CD4.
    UniProt
    P18627
    Pathways
    Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Cancer Immune Checkpoints
Sie sind hier:
Kundenservice