LAG3 Antikörper

Produktnummer ABIN1169112

Zitiert in 4+ Publikationen. Der Maus Monoklonal anti-LAG3 Antikörper (Klon 1-10E-04) (ABIN1169112) detektiert spezifisch LAG3 in WB, ELISA, IHC, ICC, IP und Func. Dieser Antikörper reagiert spezifisch mit Proben aus Human und Affe.

Kurzübersicht für LAG3 Antikörper (ABIN1169112)

Target: LAG3 (Lymphocyte-Activation Gene 3 (LAG3))

Reaktivität: Human, Affe

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser LAG3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunoprecipitation (IP), Functional Studies (Func)

Klon: 1-10E-04

Produktdetails anti-LAG3 Antikörper

Spezifität: Recognizes human and monkey LAG-3.

Kreuzreaktivität: Human, Affe

Aufreinigung: Purified from concentrated hybridoma tissue culture supernatant.

Reinheit: >95 % (SDS-PAGE)

Endotoxin-Niveau: <0.001EU/μg purified protein or <1EU/mg purified protein (LAL test, Lonza).

Immunogen: Recombinant human LAG-3.

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: In PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Short Term Storage: +4°C
Long Term Storage: -20°C
Stable for at least 1 year after receipt when stored at -20°C.

Haltbarkeit: 12 months

Referenzen für anti-LAG3 Antikörper (ABIN1169112)

Ward, Hall, Cairns, Leggat, Urbaniak, Vickers, Barker: "Clonal regulatory T cells specific for a red blood cell autoantigen in human autoimmune hemolytic anemia." in: Blood, Vol. 111, Issue 2, pp. 680-7, (2008) (PubMed).

Triebel, Hacene, Pichon: "A soluble lymphocyte activation gene-3 (sLAG-3) protein as a prognostic factor in human breast cancer expressing estrogen or progesterone receptors." in: Cancer letters, Vol. 235, Issue 1, pp. 147-53, (2006) (PubMed).

Huard, Mastrangeli, Prigent, Bruniquel, Donini, El-Tayar, Maigret, Dréano, Triebel: "Characterization of the major histocompatibility complex class II binding site on LAG-3 protein." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 94, Issue 11, pp. 5744-9, (1997) (PubMed).

Huard, Gaulard, Faure, Hercend, Triebel: "Cellular expression and tissue distribution of the human LAG-3-encoded protein, an MHC class II ligand." in: Immunogenetics, Vol. 39, Issue 3, pp. 213-7, (1994) (PubMed).

Details zu LAG3

Target: LAG3 (Lymphocyte-Activation Gene 3 (LAG3))

Andere Bezeichnung: LAG-3

Hintergrund: Lymphocyte activation gene 3 (LAG-3, CD223) plays an important role in negatively regulating T cell proliferation, function and homeostasis. It is required for maximal natural and induced regulatory T cell (Treg) function. LAG-3 is closely related to the T cell co-receptor CD4 and binds to MHC class II molecules but with a significantly higher affinity than CD4.

UniProt: P18627

Pathways: Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Cancer Immune Checkpoints