NLRP6 Antikörper

Produktnummer ABIN1169061

Der Maus Monoklonal anti-NLRP6 Antikörper (Klon Clint-1) (ABIN1169061) detektiert spezifisch NLRP6 in WB und IHC. Dieser Antikörper reagiert spezifisch mit Proben aus Human.

Kurzübersicht für NLRP6 Antikörper (ABIN1169061)

Target: NLRP6 (NLR Family, Pyrin Domain Containing 6 (NLRP6))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser NLRP6 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Klon: Clint-1

Produktdetails anti-NLRP6 Antikörper

Verwendungszweck: anti-NLRP6/NALP6 (human), mAb (Clint-1)

Spezifität: Recognizes human NLRP6.

Produktmerkmale: Monoclonal Antibody. Recognizes human NLRP6. Isotype: Mouse IgG1kappa. Clone: Clint-1. Applications: IHC, WB. Liquid. In PBS containing 10 % glycerol and 0.02 % sodium azide. The inflammasome is a multiprotein complex that mediates the activation of caspase-1, which promotes, amongst others, the secretion of the proinflammatory cytokines interleukin (IL)-1beta and IL-18. Members of the Nod-like receptor (NLR) family are critical components of the inflammasome that link danger-signals to caspase-1 activation. NLRP6/NALP6 is important for intestinal homeostasis by sensing pathogenic commensal bacteria and activating bactericidal activity of macrophages through secretion of IL-18. NLRP6 suppresses inflammation and carcinogenesis by regulating tissue repair and deletion of NLRP6 gene accelerated colitis-associated tumor growth in mice.

Aufreinigung: Purified from concentrated hybridoma tissue culture supernatant.

Reinheit: >95 % (SDS-PAGE)

Immunogen: Recombinant human NLRP6 (NACHT domain).

Isotyp: IgG1 kappa

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: In PBS containing 10 % glycerol and 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: After opening, prepare aliquots and store at -20 °C.Avoid freeze/thaw cycles.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung:

+4°C

-20°C

Stable for at least 1 year after receipt when stored at -20°C.

Haltbarkeit: 12 months

Details zu NLRP6

Target: NLRP6 (NLR Family, Pyrin Domain Containing 6 (NLRP6))

Andere Bezeichnung: NLRP6/NALP6

Hintergrund:

Alternate Names/Synonyms: NACHT-, LRR and PYD Domains-containing Protein 6, Nod-like Receptor Pyrin Domain-containing Protein 6, NLRP6, Angiotensin II/Vasopressin Receptor, PYRIN-containing APAF1-like Protein 5, NALP6

Product Description: The inflammasome is a multiprotein complex that mediates the activation of caspase-1, which promotes, amongst others, the secretion of the proinflammatory cytokines interleukin (IL)-1beta and IL-18. Members of the Nod-like receptor (NLR) family are critical components of the inflammasome that link danger-signals to caspase-1 activation. NLRP6/NALP6 is important for intestinal homeostasis by sensing pathogenic commensal bacteria and activating bactericidal activity of macrophages through secretion of IL-18. NLRP6 suppresses inflammation and carcinogenesis by regulating tissue repair and deletion of NLRP6 gene accelerated colitis-associated tumor growth in mice.

UniProt: P59044

Pathways: Inflammasome