Clusterin Antikörper

Produktnummer ABIN1169057

Der Kaninchen Polyklonal anti-Clusterin Antikörper wird verwendet zum Nachweis von Clusterin in Proben von Maus. Er wurde validiert für WB und ELISA.

Kurzübersicht für Clusterin Antikörper (ABIN1169057)

Target: Clusterin (CLU)

Reaktivität: Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Clusterin Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Produktdetails anti-Clusterin Antikörper

Verwendungszweck: anti-Clusterin (mouse), pAb

Spezifität: Recognizes mouse clusterin. Detects a band of ~48 kDa by Western blot.

Produktmerkmale: Polyclonal Antibody. Recognizes mouse clusterin. Detects a band of ~48 kDa by Western blot. Source: Rabbit. Applications: ELISA, WB. Liquid. 0.2μm-filtered solution in PBS, pH 7.4. Contains no preservatives. Clusterin shares homology with the small heat shock protein family of molecular chaperones. The mature secreted form of the protein is a glycosylated, 80- kDa disulfide-linked heterodimer of alpha and beta subunits (produced by internal cleavage). Clusterin is expressed in virtually all tissues and found in all fluids. It is involved in numerous physiological processes important for carcinogenesis and tumor growth, including apoptotic cell death, cell cycle regulation, DNA repair, cell adhesion, tissue remodeling, lipid transportation, membrane recycling, and immune system regulation. Clusterin also exists as a nuclear protein. The secreted form of Clusterin has extracellular chaperone and anti-apoptotic activities while the nuclear form acts as a proapoptotic factor.

Sterilität: 0.2 μm filtered

Immunogen: Recombinant mouse nuclear clusterin.

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: 0.2μm-filtered solution in PBS, pH 7.4.

Konservierungsmittel: Without preservative

Handhabung: After opening, prepare aliquots and store at -20 °C.Avoid freeze/thaw cycles.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung:

+4°C

-20°C

Stable for at least 6 months after receipt when stored at -20°C.

Haltbarkeit: 6 months

Details zu Clusterin

Target: Clusterin (CLU)

Andere Bezeichnung: Clusterin

Hintergrund:

Alternate Names/Synonyms: TRPM-2, Apolipoprotein J, APO-J, CLI, CLU, SGP-2

Product Description: Clusterin shares homology with the small heat shock protein family of molecular chaperones. The mature secreted form of the protein is a glycosylated, 80- kDa disulfide-linked heterodimer of alpha and beta subunits (produced by internal cleavage). Clusterin is expressed in virtually all tissues and found in all fluids. It is involved in numerous physiological processes important for carcinogenesis and tumor growth, including apoptotic cell death, cell cycle regulation, DNA repair, cell adhesion, tissue remodeling, lipid transportation, membrane recycling, and immune system regulation. Clusterin also exists as a nuclear protein. The secreted form of Clusterin has extracellular chaperone and anti-apoptotic activities while the nuclear form acts as a proapoptotic factor.

UniProt: Q06890

Pathways: Apoptose, Negative Regulation of intrinsic apoptotic Signaling