Clusterin Antikörper (Nuclear)

Produktnummer ABIN1169056

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch Clusterin in WB und ELISA. Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für Clusterin Antikörper (Nuclear) (ABIN1169056)

Target: Clusterin (CLU)

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Clusterin Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Produktdetails anti-Clusterin Antikörper

Bindungsspezifität: Nuclear

Spezifität: Recognizes human clusterin. Detects a band of ~49 kDa by Western blot.

Kreuzreaktivität: Human

Sterilität: 0.2 μm filtered

Immunogen: Recombinant human clusterin (nuclear form).

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: 0.2μm-filtered solution in PBS, pH 7.4. Contains no preservatives.

Konservierungsmittel: Without preservative

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Short Term Storage: +4°C
Long Term Storage: -20°C
Stable for at least 6 months after receipt when stored at -20°C.

Haltbarkeit: 6 months

Details zu Clusterin

Target: Clusterin (CLU)

Andere Bezeichnung: Clusterin

Hintergrund: Clusterin shares homology with the small heat shock protein family of molecular chaperones. The mature secreted form of the protein is a glycosylated, 80- kDa disulfide-linked heterodimer of alpha and beta subunits (produced by internal cleavage). Clusterin is expressed in virtually all tissues and found in all human fluids. It is involved in numerous physiological processes important for carcinogenesis and tumor growth, including apoptotic cell death, cell cycle regulation, DNA repair, cell adhesion, tissue remodeling, lipid transportation, membrane recycling, and immune system regulation. Clusterin also exists as a nuclear protein. The secreted form of Clusterin has extracellular chaperone and anti-apoptotic activities while the nuclear form acts as a proapoptotic factor.

UniProt: P10909

Pathways: Apoptose, Negative Regulation of intrinsic apoptotic Signaling