Endoglin Antikörper (AA 22-586)

Produktnummer ABIN115697

Der Kaninchen Polyklonal Anti-Endoglin-Antikörper wurde für WB, FACS und EIA validiert. Er ist geeignet, Endoglin in Proben von Human zu detektieren.

Kurzübersicht für Endoglin Antikörper (AA 22-586) (ABIN115697)

Target: Endoglin (ENG)

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Endoglin Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Flow Cytometry (FACS), Enzyme Immunoassay (EIA)

Produktdetails anti-Endoglin Antikörper

Bindungsspezifität: AA 22-586

Aufreinigung: Protein A Chromatography

Immunogen: Recombinant Human soluble CD105/Endoglin (aa. 22 (Glu) to 586 (Leu)) derived from Insect Cells

Anwendungsinformationen

Applikationshinweise: Elisa (1-15 μg/mL). Western blot (1-2 μg/mL with the appropriate secondary reagents). FACS analysis and cell sorting (2-5 μg/mL together with the appropriate secondaryreagents).
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Rekonstitution: Restore in sterile water to a concentration of 0.1-1.0 mg/mL

Buffer: PBS, pH 7.4 without preservatives

Konservierungsmittel: Without preservative

Handhabung: This product is photosensitive and should be protected from light

Lagerung: 4 °C

Informationen zur Lagerung: Prior to and following reconstitution store the antibody undiluted at 2-8 °C. DO NOT FREEZE!

Details zu Endoglin

Target: Endoglin (ENG)

Andere Bezeichnung: CD105 / Endoglin

Hintergrund: Endoglin, also known as CD105, is a Type I integral membrane glycoprotein with a large, disulfide-linked, extracellular region and a short, constitutively phosphorylated, cytoplasmic tail. Two splice variants of human endoglin, the S-endoglin and L-endoglin that differ in the length of their cytoplasmic tails have been identified. Endoglin is highly expressed on vascular endothelial cells, chondrocytes, and syncytiotrophoblasts of term placenta. It is also found on activated monocytes, bone marrow pro-erythroblasts, and leukemic cells of lymphoid and myeloid lineages. Human and mouse endoglin share approximately 70 % and 97 % amino acid sequence identity in their extracellular and intracellular domains, respectively. It has clearly been shown that CD105/Endoglin is required for angiogenesis and it plays a key role in heart development. Mutations in human endoglin or ALK-1 (another type I serine/threonine receptor) lead to the vascular disorder hereditary hemorrhagic telangiectasia (HHT). Mice heterozygous for endoglin have been developed as disease models for HHT. Endoglin has been shown to be a powerful marker of neovascularization. It is also useful as a functional marker that defines long-term repopulating hematopoietic stem cells.Synonyms: END, ENG, HHT1, ORW, ORW1

Gen-ID: 9606

UniProt: P17813