TEK Antikörper (Extracellular Domain)

Produktnummer ABIN115159

Dieser Maus Monoklonal Antikörper erkennt spezifisch TEK in WB, FACS, IHC (fro) und EIA. Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für TEK Antikörper (Extracellular Domain) (ABIN115159)

Target: TEK (TEK Tyrosine Kinase, Endothelial (TEK))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser TEK Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Flow Cytometry (FACS), Immunohistochemistry (Frozen Sections) (IHC (fro)), Enzyme Immunoassay (EIA)

Klon: Cl-16

Produktdetails anti-TEK Antikörper

Bindungsspezifität: Extracellular Domain

Spezifität: The monoclonal antibody will detect native Human TIE-2/tek in ELISA experiments and on the surface of different cell types.

Aufreinigung: Protein G Affinity Chromatoghraphy

Immunogen: Recombinant Human soluble extracellular TIE-2 protein

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: ELISA: 1-15 μg/mL. Western blotting: 1-2 μg/mL. Flow cytometry and cell sorting (FACS): 2-5 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Rekonstitution: Restore in sterile water to a concentration of 0.1-1.0 mg/mL.

Buffer: PBS, pH 7.4, without preservatives

Konservierungsmittel: Without preservative

Handhabung: Avoid repeated freeze-thaw cycles!

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: The lyophilized antibody, thought stable at room temperature, is best stored desiccated below 0 °C. Reconstituted anti-TIE-2/tek is stable at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Details zu TEK

Target: TEK (TEK Tyrosine Kinase, Endothelial (TEK))

Andere Bezeichnung: CD202b / TEK

Hintergrund: TIE2 (tyrosine kinase with Ig and EGF homology domains 2) is expressed almost exclusively in endothelial cells in mice, rats and humans. This receptor possesses a unique extracellular domain containing two immunoglobulin like loops separated by three epidermal growth factor like repeats that are connected to three fibronectin type III like repeats. The ligand for the receptor is Angiopoietin 1. Defects in TIE2 are associated with inherited venous malformations, the TIE2 signaling pathway appears to be critical for endothelial cell smooth muscle cell communication in venous morphogenesis.Synonyms: Angiopoietin-1 receptor, TIE-2, TIE2, Tunica interna endothelial cell kinase, Tyrosine-protein kinase receptor TEK, Tyrosine-protein kinase receptor TIE-2, p140 TEK

Gen-ID: 7010

NCBI Accession: NP_000450

UniProt: Q02763

Pathways: RTK Signalweg, Growth Factor Binding