Liver Arginase Antikörper

Produktnummer ABIN114697

Dieses Maus Monoklonal-Antikörper erkennt spezifisch Liver Arginase in WB und EIA. Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für Liver Arginase Antikörper (ABIN114697)

Target: Liver Arginase (ARG1) (Arginase, Liver (ARG1))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser Liver Arginase Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Enzyme Immunoassay (EIA)

Klon: 6G3

Produktdetails anti-Liver Arginase Antikörper

Spezifität: The Anti Human Arginase, Clone 6G3 is a Mouse monoclonal antibody against recombinant Human Arginase-liver type Arginase.

Aufreinigung: Purified

Immunogen: Recombinant human liver-type aginase produced in E. coli.

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: ELISA. Western Blot.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Rekonstitution: Add 0.1 mL of deionized water and let the lyophilized pellet dissolve completely. Slight turbidity may occur after reconstitution, which does not affect activity of the antibody. In this case clarify the solution by centrifugation.

Konzentration: 1.0 mg/mL

Buffer: 0.05 M Phosphate buffer, 0.5 M NaCl, pH 7.2, None

Konservierungsmittel: Azide free

Handhabung: Avoid repeated freezing and thawing.

Lagerung: -20 °C

Informationen zur Lagerung: Prior to reconstitution store at -70 °C. Following reconstitution store the antibody (in aliquots) at -20 °C for 6 month.

Haltbarkeit: 6 months

Details zu Liver Arginase

Target: Liver Arginase (ARG1) (Arginase, Liver (ARG1))

Andere Bezeichnung: Arginase-1

Hintergrund: Arginase [EC 3.5.3.1, L-arginine aminohydrolase] is an enzyme that hydrolyzes Larginine to L-ornithine and urea in the urea cycle. Two forms of arginase exists which are designed as arginase I and arginase II. Livertype arginase I is expressed primarily in the liver and to some extend in the erythrocytes. Arginase II is expressed in many extrahepatic tissues, such as brain, spinal cord, kidney, small intestine and mammary gland. Although arginase I and arginase II have similar enzyme activities, they have different pI, immunological reactivity and are encoded by different genes. Human arginase I is a 35 kDa protein circulating in blood probably as a homotrimer. Circulating liver-type arginase was clinically used as a liver specific marker which may reflect not only early occurrence of liver injury but also early termination of liver injury. The measurement of liver-type arginase is clinically applicable for monitoring conditions of patients with liver disorders or pre- and postoperative conditions of patients who received partial hepatectomy with quicker normalization in comparison with aminotransferases (ALT and AST). Recently, arginase I gene was found to be one of the most prominent among astma genes. In situ hybridization demonstrated marked staining of arginase I in submucosal inflammatory lesions and arginase activity increased in allergen challenged lungs. Finally, it was found that both arginase I was the most significantly up-regulated protein in the murine spinal cord during experimental autoimmune encephalomyelitis. The results indicated that arginase I played important roles in autoimmune inflammation in the central nervous system.Synonyms: ARG1, Liver-type arginase, Type I arginase

Gen-ID: 383

NCBI Accession: NP_000036

UniProt: P05089

Pathways: Cellular Response to Molecule of Bacterial Origin